Calcium-activated potassium channels: Implications for aging and age-related neurodegeneration

Marina Trombetta-Lima, Inge E. Krabbendam, Amalia M. Dolga*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

9 Citations (Scopus)
98 Downloads (Pure)

Abstract

Population aging, as well as the handling of age-associated diseases, is a worldwide increasing concern. Among them, Alzheimer's disease stands out as the major cause of dementia culminating in full dependence on other people for basic functions. However, despite numerous efforts, in the last decades, there was no new approved therapeutic drug for the treatment of the disease. Calcium-activated potassium channels have emerged as a potential tool for neuronal protection by modulating intracellular calcium signaling. Their subcellular localization is determinant of their functional effects. When located on the plasma membrane of neuronal cells, they can modulate synaptic function, while their activation at the inner mitochondrial membrane has a neuroprotective potential via the attenuation of mitochondrial reactive oxygen species in conditions of oxidative stress. Here we review the dual role of these channels in the aging phenotype and Alzheimer's disease pathology and discuss their potential use as a therapeutic tool.

Original languageEnglish
Article number105748
Number of pages10
JournalInternational journal of biochemistry & cell biology
Volume123
DOIs
Publication statusPublished - Jun-2020

Keywords

  • Aging
  • Mitochondrial ROS
  • Mitohormesis
  • Neuroprotection
  • Memory
  • Potassium channels
  • CA2+-ACTIVATED K+ CHANNEL
  • CA1 PYRAMIDAL NEURONS
  • SMALL-CONDUCTANCE
  • INTERMEDIATE-CONDUCTANCE
  • AMYLOID-BETA
  • SK2 CHANNELS
  • BK CHANNELS
  • SYNAPTIC PLASTICITY
  • ALZHEIMERS-DISEASE
  • NITRIC-OXIDE

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