Calcium in milk products precipitates intestinal fatty acids and secondary bile acids and thus inhibits colonic cytotoxicity in humans

MJAP Govers, DSML Termont, JA Lapre, JH Kleibeuker, RJ Vonk, R VanderMeer

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127 Citations (Scopus)

Abstract

Dietary calcium may reduce the risk of colon cancer, probably by precipitating cytotoxic surfactants, such as secondary bile acids, in the colonic lumen. We previously showed that milk mineral, an important source of calcium, decreases metabolic risk factors and colonic proliferation in rats, We non report the effects of the habitual intake of milk calcium on metabolic risk factors in healthy subjects. A double-blind, cross-over metabolic study was performed in 13 healthy males, Placebo milk products (calcium, 3 mM) were compared with regular milk products (calcium, 30 mM), In each 1-week period, the habitual diet was recorded, and urine and feces were collected for 1 and 3 days, respectively. Milk calcium significantly increased fecal pH and fecal excretion of phosphate (132%), total fat (139%), free fatty acids (195%), and bile acids (141%), indicating intestinal complexation. In fecal water, the concentrations of long-chain fatty acids, secondary bile acids (deoxycholic and lithocholic acid), neutral sterols, and phospholipids were about halved (P <0.05), Consistent with these changes in soluble hydrophobic surfactants, calcium decreased the cytotoxicity of fecal crater from 68 +/- 9 to 28 +/- 12% (P <0.005), Calcium in milk products precipitates luminal cytotoxic surfactants and thus inhibits colonic cytotoxicity. Therefore, habitual dietary calcium may contribute to a nutritional modulation of colon cancer risk.

Original languageEnglish
Pages (from-to)3270-3275
Number of pages6
JournalCancer Research
Volume56
Issue number14
Publication statusPublished - 15-Jul-1996

Keywords

  • SUPPLEMENTAL DIETARY CALCIUM
  • FECAL WATER
  • EPITHELIAL PROLIFERATION
  • CELL-PROLIFERATION
  • ADENOMATOUS POLYPS
  • CYTOLYTIC ACTIVITY
  • CANCER PREVENTION
  • DEOXYCHOLIC-ACID
  • PHOSPHATE
  • RISK

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