Abstract
The light response of fly photoreceptor cells is modulated by changes in free Ca2+ concentration. Fly phototransduction and most processes regulating it take place in or very close to the rhabdomere. We therefore measured the kinetics and the absolute values of the free Ca2+ concentration in the rhabdomere of fly photoreceptor cells in vivo by making use of the natural optics of the fly's eye. We show that Ca2+ flowing into the rhabdomere after light stimulation of dark-adapted cells causes fast Ca2+ transients that reach peak values higher than 200 mu M in
| Original language | English |
|---|---|
| Pages (from-to) | 1701-1709 |
| Number of pages | 9 |
| Journal | The Journal of Neuroscience |
| Volume | 20 |
| Issue number | 5 |
| Publication status | Published - 1-Mar-2000 |
Keywords
- phototransduction
- light adaptation
- Ca2+ transients
- local Ca2+ signaling
- Ca2+ feedback
- fluorescent Ca2+ indicators
- LIMULUS VENTRAL PHOTORECEPTORS
- PDZ DOMAIN PROTEIN
- DROSOPHILA PHOTORECEPTORS
- CA2+ CONCENTRATION
- SENSITIVE CHANNELS
- SIGNALING COMPLEX
- IN-VIVO
- EXTRACELLULAR CALCIUM
- KINASE-C
- TRP