Objectives: The aim of this study is to determine a set of MRI lymph node characteristics predictive for extranodal tumor spread (ENS) in head and neck cancer patients.
Methods: In 39 patients, 60 lymph nodes with on MRI a minimal axial diameter of more than 1 cm or an inhomogeneous enhancement were studied. Two radiologists evaluated all MR-images for findings potentially indicative of the presence of ENS. Sensitivity, specificity and odds ratios based on logistic regression were calculated.
Results: On MR-imaging, 20 lymph nodes were staged positive for ENS. On histopathology, 30 nodes were positive for ENS. In total, 14 nodes (23%) were scored differently on MR-imaging and histopathology. The MR-finding "infiltration of adjacent planes" established a specificity of 100% (lower 90% confidence bound: 91%) and sensitivity of 50% (95% confidence interval [CI]: 28-72%).
Conclusion: The MRI finding "infiltration of adjacent planes" may be high enough (100% in our study) to be used for treatment planning. (C) 2013 Elsevier Ltd. All rights reserved.
|Number of pages||8|
|Publication status||Published - Jun-2013|
- Extranodal spread
- MR imaging
- Head and neck cancer
- Lymph node
- SQUAMOUS-CELL CARCINOMA
- LYMPH-NODE METASTASIS
- EXTRACAPSULAR SPREAD
- POSTOPERATIVE RADIOTHERAPY
- NEOPLASTIC SPREAD