Cancer-drug induced insulin resistance: Innocent bystander or unusual suspect

G. Ariaans, S. de Jong, J. A. Gietema, J. D. Lefrandt, E. G. E. de Vries, M. Jalving*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)

Abstract

Epidemiological and experimental evidence strongly suggests an association between type 2 diabetes mellitus and cancer. Insulin resistance, causing hyperinsulinaemia and eventually hyperglycaemia, appears to increase cancer incidence and disease progression. In addition, insulin resistance seems to reduce the efficacy of cancer therapy. Treatment with cancer therapeutics such as glucocorticoids, chemotherapy, hormonal therapies and targeted drugs can actually induce insulin resistance. The question arises whether cancer-therapy induced insulin resistance impairs anticancer treatment efficacy and disease outcome. Here, we review current literature regarding the incidence of cancer-therapy induced insulin resistance and describe the systemic and extra- and intracellular changes that occur in insulin signalling pathways and glucose metabolism. Subsequently, clinical and preclinical evidence for consequences of insulin resistance in terms of cancer progression and survival is presented. Finally, potential interventions including diabetes medication and limiting energy availability through diets and exercise are discussed. (C) 2015 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)376-384
Number of pages9
JournalCANCER TREATMENT REVIEWS
Volume41
Issue number4
DOIs
Publication statusPublished - Apr-2015

Keywords

  • Cancer
  • Insulin resistance
  • Diabetes
  • Cancer therapy
  • Metformin
  • Fasting
  • ANDROGEN DEPRIVATION THERAPY
  • ACUTE LYMPHOBLASTIC-LEUKEMIA
  • FASTING BLOOD-GLUCOSE
  • BODY-MASS INDEX
  • BREAST-CANCER
  • METABOLIC SYNDROME
  • PROSTATE-CANCER
  • COLORECTAL-CANCER
  • DIABETES-MELLITUS
  • POSTMENOPAUSAL WOMEN

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