Cardiac complications in patients hospitalised with COVID-19

CAPACITY-COVID Collaborative Conso, Marijke Linschoten, Sanne Peters, Maarten van Smeden, Lucia S. Jewbali, Jeroen Schaap, Hans-Marc Siebelink, Peter C. Smits, Robert G. Tieleman, Pim van der Harst, Wiek H. van Gilst, Folkert W. Asselbergs*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

98 Citations (Scopus)
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Abstract

Aims:

To determine the frequency and pattern of cardiac complications in patients hospitalised with coronavirus disease (COVID-19).

Methods and results:

CAPACITY-COVID is an international patient registry established to determine the role of cardiovascular disease in the COVID-19 pandemic. In this registry, data generated during routine clinical practice are collected in a standardised manner for patients with a (highly suspected) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection requiring hospitalisation. For the current analysis, consecutive patients with laboratory confirmed COVID-19 registered between 28 March and 3 July 2020 were included. Patients were followed for the occurrence of cardiac complications and pulmonary embolism from admission to discharge. In total, 3011 patients were included, of which 1890 (62.8%) were men. The median age was 67 years (interquartile range 56-76); 937 (31.0%) patients had a history of cardiac disease, with pre-existent coronary artery disease being most common (n=463, 15.4%). During hospitalisation, 595 (19.8%) patients died, including 16 patients (2.7%) with cardiac causes. Cardiac complications were diagnosed in 349 (11.6%) patients, with atrial fibrillation (n=142, 4.7%) being most common. The incidence of other cardiac complications was 1.8% for heart failure (n=55), 0.5% for acute coronary syndrome (n=15), 0.5% for ventricular arrhythmia (n=14), 0.1% for bacterial endocarditis (n=4) and myocarditis (n=3), respectively, and 0.03% for pericarditis (n=1). Pulmonary embolism was diagnosed in 198 (6.6%) patients.

Conclusion:

This large study among 3011 hospitalised patients with COVID-19 shows that the incidence of cardiac complications during hospital admission is low, despite a frequent history of cardiovascular disease. Long-term cardiac outcomes and the role of pre-existing cardiovascular disease in COVID-19 outcome warrants further investigation.

Original languageEnglish
Pages (from-to)817-823
Number of pages7
JournalEuropean Heart Journal: Acute Cardiovascular Care
Volume9
Issue number8
DOIs
Publication statusPublished - Dec-2020

Keywords

  • COVID-19
  • coronavirus
  • cohorts
  • patient registry
  • cardiac complications
  • pulmonary embolism
  • 2015 ESC GUIDELINES
  • EUROPEAN-SOCIETY
  • TASK-FORCE
  • MYOCARDITIS
  • MANAGEMENT
  • DIAGNOSIS
  • ASSOCIATION
  • TROPONIN

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