Cardiac function after chemoradiation for esophageal cancer: Comparison of heart dose-volume histogram parameters to multiple gated acquisition scan changes

P Tripp, H K Malhotra, M Javle, A Shaukat, R Russo, Sietse de Boer, M Podgorsak, H Nava, G Y Yang*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    32 Citations (Scopus)


    In this paper we determine if preoperative chemoradiation for locally advanced esophageal cancer leads to changes in cardiac ejection fraction. This is a retrospective review of 20 patients treated at our institution for esophageal cancer between 2000 and 2002. Multiple gated acquisition cardiac scans were obtained before and after platinum-based chemoradiation (50.4 Gy). Dose-volume histograms for heart, left ventricle and left anterior descending artery were analyzed. Outcomes assessed included pre- and postchemoradiation ejection fraction ratio and percentage change in ejection fraction postchemoradiation. A statistically significant difference was found between median prechemoradiation ejection fraction (59%) and postchemoradiation ejection fraction (54%) (P = 0.01), but the magnitude of the difference was not clinically significant. Median percentage volume of heart receiving more than 20, 30 and 40 Gy were 61.5%, 58.5% and 53.5%, respectively. Our data showed a clinically insignificant decline in ejection fraction following chemoradiation for esophageal cancer. We did not observe statistically or clinically significant associations between radiation dose to heart, left ventricle or left anterior descending artery and postchemoradiation ejection fraction.

    Original languageEnglish
    Pages (from-to)400-405
    Number of pages6
    JournalDiseases of the esophagus
    Issue number6
    Publication statusPublished - 2005


    • Aged
    • Antineoplastic Combined Chemotherapy Protocols
    • Cisplatin
    • Combined Modality Therapy
    • Dose Fractionation
    • Esophageal Neoplasms
    • Evaluation Studies as Topic
    • Female
    • Fluorouracil
    • Gated Blood-Pool Imaging
    • Heart
    • Humans
    • Male
    • Middle Aged
    • Radiotherapy Dosage
    • Retrospective Studies
    • Stroke Volume

    Cite this