Cardiac Function and Architecture Are Maintained in a Model of Cardiorestricted Overexpression of the Prorenin-Renin Receptor

Hasan Mahmud; Wellington Mardoqueu Candido; Linda van Genne; Inge Vreeswijk-Baudoin; Hongjuan Yu; Bart van de Sluis; Jan van Deursen; Wiek H. van Gilst; Herman H. W. Sillje; Rudolf A. de Boer

doi:10.1371/journal.pone.0089929

Cardiac Function and Architecture Are Maintained in a Model of Cardiorestricted Overexpression of the Prorenin-Renin Receptor

Hasan Mahmud
, Wellington Mardoqueu Candido
, Linda van Genne
, Inge Vreeswijk-Baudoin
, Hongjuan Yu
, Bart van de Sluis
, Jan van Deursen
, Wiek H. van Gilst
, Herman H. W. Sillje
, Rudolf A. de Boer^*

^*Corresponding author for this work

Cardiovascular Centre (CVC)

Research output: Contribution to journal › Article › Academic › peer-review

15 Citations (Scopus)

379 Downloads (Pure)

Abstract

The (pro) renin-renin receptor, (P) RR has been claimed to be a novel element of the renin-angiotensin system (RAS). The function of (P) RR has been widely studied in renal and vascular pathology but the cardio-specific function of (P)RR has not been studied in detail. We therefore generated a transgenic mouse (Tg) with cardio-restricted (P) RR overexpression driven by the alpha-MHC promotor. The mRNA expression of (P) RR was similar to 170-fold higher (P

Original language	English
Article number	e89929
Number of pages	9
Journal	PLoS ONE
Volume	9
Issue number	2
DOIs	https://doi.org/10.1371/journal.pone.0089929
Publication status	Published - 25-Feb-2014

Keywords

HUMAN (PRO)RENIN RECEPTOR
TRANSGENIC RATS
RENIN/PRORENIN RECEPTOR
HYPERTROPHY
ACTIVATION
BINDING
CELLS
MICE
GLOMERULOSCLEROSIS
HYPERTENSION

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Cardiac Function and Architecture Are Maintained in a Model of Cardiorestricted Overexpression of the Prorenin-Renin ReceptorFinal publisher's version, 2.19 MBLicence: CC BY

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Mahmud, H., Candido, W. M., van Genne, L., Vreeswijk-Baudoin, I., Yu, H., van de Sluis, B., van Deursen, J., van Gilst, W. H., Sillje, H. H. W., & de Boer, R. A. (2014). Cardiac Function and Architecture Are Maintained in a Model of Cardiorestricted Overexpression of the Prorenin-Renin Receptor. PLoS ONE, 9(2), Article e89929. https://doi.org/10.1371/journal.pone.0089929

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title = "Cardiac Function and Architecture Are Maintained in a Model of Cardiorestricted Overexpression of the Prorenin-Renin Receptor",

abstract = "The (pro) renin-renin receptor, (P) RR has been claimed to be a novel element of the renin-angiotensin system (RAS). The function of (P) RR has been widely studied in renal and vascular pathology but the cardio-specific function of (P)RR has not been studied in detail. We therefore generated a transgenic mouse (Tg) with cardio-restricted (P) RR overexpression driven by the alpha-MHC promotor. The mRNA expression of (P) RR was similar to 170-fold higher (P",

keywords = "HUMAN (PRO)RENIN RECEPTOR, TRANSGENIC RATS, RENIN/PRORENIN RECEPTOR, HYPERTROPHY, ACTIVATION, BINDING, CELLS, MICE, GLOMERULOSCLEROSIS, HYPERTENSION",

author = "Hasan Mahmud and Candido, \{Wellington Mardoqueu\} and \{van Genne\}, Linda and Inge Vreeswijk-Baudoin and Hongjuan Yu and \{van de Sluis\}, Bart and \{van Deursen\}, Jan and \{van Gilst\}, \{Wiek H.\} and Sillje, \{Herman H. W.\} and \{de Boer\}, \{Rudolf A.\}",

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doi = "10.1371/journal.pone.0089929",

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AU - Mahmud, Hasan

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AU - van Genne, Linda

AU - Vreeswijk-Baudoin, Inge

AU - Yu, Hongjuan

AU - van de Sluis, Bart

AU - van Deursen, Jan

AU - van Gilst, Wiek H.

AU - Sillje, Herman H. W.

AU - de Boer, Rudolf A.

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KW - HYPERTROPHY

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KW - BINDING

KW - CELLS

KW - MICE

KW - GLOMERULOSCLEROSIS

KW - HYPERTENSION

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Cardiac Function and Architecture Are Maintained in a Model of Cardiorestricted Overexpression of the Prorenin-Renin Receptor

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