Cardiovascular risk management in people with type 1 diabetes: performance using three guidelines

Rita Delphine Maiko Varkevisser, Erwin Birnie, Charlotte E Vollenbrock, Dick Mul, Peter R van Dijk, Melanie M van der Klauw, Henk Veeze, Bruce H R Wolffenbuttel, Henk-Jan Aanstoot

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Abstract

INTRODUCTION: Cardiovascular disease (CVD) is the leading cause of mortality in individuals with type 1 diabetes mellitus (T1DM). Cardiovascular risk management is therefore essential in the management of individuals with T1DM. This study describes the performance of lipid and blood pressure management in individuals with T1DM using three guidelines.

RESEARCH DESIGN AND METHODS: Individuals ≥18 years with T1DM, treated with insulin for ≥1 year, visiting Diabeter or the University Medical Center Groningen between January 1, 2018 and December 31, 2018, were included. Lipid and blood pressure management were examined using the Dutch, American Diabetes Association (ADA) and National Institute for Health and Care Excellence (NICE) guidelines. Concordance of recommended and prescribed lipid-lowering (LLM) or antihypertensive medication (AHM) was assessed per guideline and 10-year age groups. Achievement of treatment targets was assessed for those prescribed medication.

RESULTS: A total of 1855 individuals with T1DM were included. LLM and AHM was prescribed in 19% and 17%, respectively. In individuals recommended LLM, this was prescribed in 22%-46% according to Dutch, ADA or NICE guideline recommendations. For individuals recommended AHM, this was prescribed in 52%-75%. Recommended and actual prescription of LLM and AHM increased over age for all three guidelines. However, discordance between treatment recommendation and medication prescribed was higher in younger, compared with older, age groups. Low-density lipoprotein-cholesterol targets were achieved by 50% (without CVD) and 31% (with CVD) of those prescribed LLM. The blood pressure target was achieved by 46% of those prescribed AHM.

CONCLUSION: This study suggests that there is undertreatment of lipid and blood pressure according to guideline recommendations, particularly in younger age groups. Treatment targets are not met by most individuals prescribed medication, while guidelines recommendations differ considerably. We recommend to investigate the factors influencing undertreatment of lipid and blood pressure management in individuals with T1DM.

Original languageEnglish
Article numbere002765
Number of pages19
JournalBMJ Open Diabetes Research & Care
Volume10
Issue number4
DOIs
Publication statusE-pub ahead of print - 20-Jul-2022

Keywords

  • Antihypertensive Agents/therapeutic use
  • Cardiovascular Diseases/epidemiology
  • Cholesterol, LDL
  • Diabetes Mellitus, Type 1/complications
  • Heart Disease Risk Factors
  • Humans
  • Risk Factors

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