Purpose: A recent report showed no benefit of the leptin: adiponectin ratio (L: A ratio) over individual adipokine levels in CHD prediction [ 8]. We determined associations of carotid intima media thickness (IMT) with the L: A ratio taking account of cardiovascular risk factors in a high risk population.
Methods: IMT, plasma leptin, adiponectin and the L: A ratio were determined in 161 middle-aged men and women (45% metabolic syndrome).
Results: IMT was associated inversely with adiponectin and positively with the L: A ratio in age- and sex-adjusted multiple linear regression analyses (P <0.001 for both). After controlling for metabolic syndrome, the independent association with adiponectin remained (P <0.001), but the relationship with the L: A ratio disappeared (P = 0.126). Results were similar after additional adjustment for diabetes status or for insulin resistance.
Conclusion: This study does not support the preferential use of the leptin: adiponectin ratio as a marker of atherosclerosis susceptibility. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
|Number of pages||4|
|Publication status||Published - Aug-2010|
- Intima media thickness
- Leptin: adiponectin ratio
- Metabolic syndrome
- TYPE-2 DIABETES-MELLITUS
- EARLY ATHEROSCLEROSIS