Carotid intima media thickness is associated with plasma adiponectin but not with the leptin: adiponectin ratio independently of metabolic syndrome

Robin P. F. Dullaart*, Paul J.W.H. Kappelle, Geesje M. Dallinga-Thie

*Corresponding author for this work

    Research output: Contribution to journalLetterAcademicpeer-review

    27 Citations (Scopus)


    Purpose: A recent report showed no benefit of the leptin: adiponectin ratio (L: A ratio) over individual adipokine levels in CHD prediction [ 8]. We determined associations of carotid intima media thickness (IMT) with the L: A ratio taking account of cardiovascular risk factors in a high risk population.

    Methods: IMT, plasma leptin, adiponectin and the L: A ratio were determined in 161 middle-aged men and women (45% metabolic syndrome).

    Results: IMT was associated inversely with adiponectin and positively with the L: A ratio in age- and sex-adjusted multiple linear regression analyses (P <0.001 for both). After controlling for metabolic syndrome, the independent association with adiponectin remained (P <0.001), but the relationship with the L: A ratio disappeared (P = 0.126). Results were similar after additional adjustment for diabetes status or for insulin resistance.

    Conclusion: This study does not support the preferential use of the leptin: adiponectin ratio as a marker of atherosclerosis susceptibility. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)393-396
    Number of pages4
    Issue number2
    Publication statusPublished - Aug-2010


    • Adiponectin
    • Intima media thickness
    • Leptin
    • Leptin: adiponectin ratio
    • Metabolic syndrome
    • ARTERY
    • INDEX

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