Catalytic enantioselective conjugate addition of dialkylzinc reagents to N-substituted-2,3-dehydro-4-piperidones

Radovan Šebesta; Maria Gabriella Pizzuti; Arnold J. Boersma; Adriaan J. Minnaard; Ben L. Feringa

doi:10.1039/b417727d

Catalytic enantioselective conjugate addition of dialkylzinc reagents to N-substituted-2,3-dehydro-4-piperidones

Radovan Šebesta, Maria Gabriella Pizzuti, Arnold J. Boersma, Adriaan J. Minnaard, Ben L. Feringa

Research output: Contribution to journal › Article › Academic › peer-review

62 Citations (Scopus)

73 Downloads (Pure)

Abstract

The first, highly enantioselective, copper/phosphoramidite-catalyzed conjugate addition of dialkylzinc reagents to N-substituted 2,3-dehydro-4-piperidones is described.

Original language	English
Pages (from-to)	1711-1713
Number of pages	3
Journal	Chemical Communications
Issue number	13
DOIs	https://doi.org/10.1039/b417727d
Publication status	Published - 2005

Keywords

ORGANOZINC REAGENTS
ASYMMETRIC 1,4-ADDITION
NUCLEOPHILES
ALDEHYDES
LIGANDS
ROUTE

Access to Document

10.1039/b417727d

Handle.net

Persistent link

Embargoed Document

2005ChemCommSebestaSupp.pdf
Final publisher's version, 162 KB
Request copy

Embargoed Document

2005ChemCommSebesta.pdf
Final publisher's version, 210 KB
Request copy

Cite this

@article{10acac83c6534f7f9b1771ca8547ddc5,

title = "Catalytic enantioselective conjugate addition of dialkylzinc reagents to N-substituted-2,3-dehydro-4-piperidones",

abstract = "The first, highly enantioselective, copper/phosphoramidite-catalyzed conjugate addition of dialkylzinc reagents to N-substituted 2,3-dehydro-4-piperidones is described.",

keywords = "ORGANOZINC REAGENTS, ASYMMETRIC 1,4-ADDITION, NUCLEOPHILES, ALDEHYDES, LIGANDS, ROUTE",

author = "Radovan {\v S}ebesta and Pizzuti, {Maria Gabriella} and Boersma, {Arnold J.} and Minnaard, {Adriaan J.} and Feringa, {Ben L.}",

year = "2005",

doi = "10.1039/b417727d",

language = "English",

pages = "1711--1713",

journal = "Chemical Communications (Cambridge, United Kingdom)",

issn = "1359-7345",

publisher = "ROYAL SOC CHEMISTRY",

number = "13",

}

TY - JOUR

T1 - Catalytic enantioselective conjugate addition of dialkylzinc reagents to N-substituted-2,3-dehydro-4-piperidones

AU - Šebesta, Radovan

AU - Pizzuti, Maria Gabriella

AU - Boersma, Arnold J.

AU - Minnaard, Adriaan J.

AU - Feringa, Ben L.

PY - 2005

Y1 - 2005

N2 - The first, highly enantioselective, copper/phosphoramidite-catalyzed conjugate addition of dialkylzinc reagents to N-substituted 2,3-dehydro-4-piperidones is described.

AB - The first, highly enantioselective, copper/phosphoramidite-catalyzed conjugate addition of dialkylzinc reagents to N-substituted 2,3-dehydro-4-piperidones is described.

KW - ORGANOZINC REAGENTS

KW - ASYMMETRIC 1,4-ADDITION

KW - NUCLEOPHILES

KW - ALDEHYDES

KW - LIGANDS

KW - ROUTE

U2 - 10.1039/b417727d

DO - 10.1039/b417727d

M3 - Article

SP - 1711

EP - 1713

JO - Chemical Communications (Cambridge, United Kingdom)

JF - Chemical Communications (Cambridge, United Kingdom)

SN - 1359-7345

IS - 13

ER -