Catalytic Regio- and Enantioselective Alkylation of Conjugated Dienyl Amides

Yafei Guo, Johanan Kootstra, Syuzanna R. Harutyunyan

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9 Citations (Scopus)


A method for catalytic asymmetric alkylation of conjugated dienyl amides has been developed and it allows efficient and high-yielding transformations of a wide range of polyconjugated amides into the corresponding chiral products. Smooth addition of organomagnesium reagents to relatively unreactive dienyl amides with excellent 1,6- and 1,4-selectivities, as well as enantioselectivites above 90  is achieved owing to the complementary action of the Lewis acid and a chiral copper-based catalyst.
Original languageEnglish
Pages (from-to)13547-13550
Number of pages4
JournalAngewandte Chemie International Edition
Issue number41
Publication statusPublished - 8-Oct-2018


  • asymmetric catalysis
  • conjugation
  • copper
  • Lewis acids
  • regioselectivity

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