Abstract
Background and Aims: The negative effects of chronic low-level inflammation on adipose tissue physiology have been extensively demonstrated, whereas the effects of acute inflammation are less studied. Here, we aimed to investigate the effects of sepsis-induced acute inflammation on gene expression markers of brown and white adipose tissue functionality.
Methods: Brown adipose tissue (BAT) and perirenal white adipose tissue (prWAT) gene expression markers were analyzed in cecal ligation and puncture (CLP)-induced sepsis mice model.
Results: CLP-induced sepsis attenuated expression of adipogenesis-related genes, in parallel to increased Tnf, Il6, and Ltf gene expression in prWAT. In contrast, CLP-induced sepsis resulted in increased expression of pro-inflammatory genes (Il6, Ltf, and Lbp) in BAT, without affecting expression of genes encoding for thermogenic activity.
Conclusion: Sepsis promotes both prWAT and BAT inflammation, associated with reduced adipogenesis-related gene expression in prWAT, without significant effects on BAT thermogenic genes.
| Original language | English |
|---|---|
| Article number | 692618 |
| Pages (from-to) | 1-8 |
| Number of pages | 8 |
| Journal | Frontiers in Physiology |
| Volume | 12 |
| DOIs | |
| Publication status | Published - 12-Jul-2021 |
Keywords
- cecal ligation and puncture
- inflammation
- sepsis
- brown adipose tissue
- white adipose tissue
- OBESITY
- INTERLEUKIN-6
- SURVIVAL
- 3T3-L1
- INJURY
- MICE
- ADIPOGENESIS
- PIOGLITAZONE
- SUPPRESSES
- ALPHA