Cell adaptation upon stress: the emerging role of membrane-less compartments

Catherine Rabouille, Simon Alberti

    Research output: Contribution to journalReview articlepeer-review

    51 Citations (Scopus)

    Abstract

    Cells under stress transition from a growth to a quiescent state. The conventional thinking is that this is achieved through transcriptional programs, translational regulation, protein degradation, and post-translational modifications. However, there is an increasing realization that stress adaptation also goes along with dramatic changes in the architecture and organization of cells. In particular, it seems to involve the formation of membrane-less compartments and macromolecular assemblies. We propose that cells make widespread use of this ability to change macromolecular organization to adapt to stress conditions and protect themselves.

    Here, we address what triggers the formation of these assemblies under stress conditions. We present examples illustrating that in some cases, sophisticated signaling pathways transmit environmental fluctuations from the outside to the inside and in others, that external fluctuations directly affect the internal conditions in cells. We further argue that changes in the organization of the cytoplasm and the formation of membrane-less compartments have many advantages over other ways of altering protein function, such as protein degradation, translation or transcription. Furthermore, membrane-less compartments may act as protective devices for key cellular components.

    Original languageEnglish
    Pages (from-to)34-42
    Number of pages9
    JournalCurrent Opinion in Cell Biology
    Volume47
    DOIs
    Publication statusPublished - Aug-2017

    Keywords

    • HEAT-SHOCK GRANULES
    • PROTEIN AGGREGATION
    • METABOLIC ENZYMES
    • PHASE-TRANSITIONS
    • CYTOSOLIC PH
    • DROSOPHILA
    • CYTOPLASM
    • DORMANCY
    • SPORES
    • YEAST

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