Cell-free chemoenzymatic cascades with bio-based molecules

Henrik Terholsen, Sandy Schmidt*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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For the valorization of various bio-based feedstocks, the combination of different catalytic systems with biocatalysis in chemoenzymatic cascades has been shown to have high potential. However, the development of such integrated catalytic systems is often limited by catalyst incompatibility. Therefore, incorporating novel catalytic concepts into the chemoenzymatic valorization of bio-based feedstocks is currently of great interest. This article provides an overview of the methods/approaches used to advance the development of chemoenzymatic cascades for the catalytic upgrading of bio-based feedstocks. It specifically focuses on recent developments in the combination of enzymes with organo- and chemocatalysis. Furthermore, current applications and future perspectives of integrating novel catalytic systems such as photo- and electrocatalysis toward new synthetic routes for the utilization of the often highly functionalized bio-based compounds are reviewed.
Original languageEnglish
Article number103058
Number of pages11
JournalCurrent Opinion in Biotechnology
Early online date27-Dec-2023
Publication statusPublished - Feb-2024


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