Cell-specific delivery of biologicals: Problems, pitfalls and possibilities of antifibrotic compounds in the liver

Klaas Poelstra*, Leonie Beljaars, Barbro N Melgert

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)

Abstract

Liver fibrosis is a complex disease affecting millions of people world-wide. It involves the activation of several cell types whose activities are tightly controlled by endogenous mediators. No pharmacotherapy is available for this disease, despite the fact that many experimental drugs are very effective in vitro and the liver is easily accessible for most drugs. Our review provides arguments showing that cell-selectivity is essential for most antifibrotics. Several cell-specific drug carriers targeting the key pathogenic liver cells are discussed with special focus on hepatic stellate cells and fibroblast-like cells. Since endogenous mediators represent a powerful set of tools to modify the pathogenic process, this review focuses on these mediators as therapeutics and the problems and pitfalls associated with the use of such biologicals.

Original languageEnglish
Pages (from-to)1237-1242
Number of pages6
JournalDrug Discovery Today
Volume18
Issue number23-24
DOIs
Publication statusPublished - Dec-2013

Keywords

  • HEPATIC STELLATE CELLS
  • GROWTH-FACTOR-BETA
  • MACROPHAGE ACTIVATION
  • TARGETED LIPOSOMES
  • INTERFERON-GAMMA
  • TGF-BETA
  • FIBROSIS
  • CIRRHOSIS
  • DRUGS
  • RAT

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