Cellular interactions of biodegradable nanorod arrays prepared by nondestructive extraction from nanoporous alumina

Silko Grimm, Jaime Martin, Gema Rodriguez, Mar Fernandez-Gutierrez, Klaus Mathwig, Ralf B. Wehrspohn, Ulrich Goesele, Julio San Roman, Carmen Mijangos, Martin Steinhart*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Scopus)

Abstract

Biodegradable extracellular matrices (ECMs) consisting of mechanically stable arrays of aligned poly(lactide) nanorods (nanorod diameter approximate to 200 nm; lattice constant approximate to 500 nm) with areas up to 9 cm(2) were prepared by nondestructive extraction from recyclable self-ordered nanoporous alumina hard templates. Fibroblasts formed dense tissue layers on the heparin/gelatin activated nanorod arrays, showed excellent adhesion and exhibited a highly elongated morphology such as in natural tissue. The synthetic approach reported here combining advantages of top-down lithography (well-defined topography) and self-assembly (low costs, high throughput, feature size in the 100 nm range) may yield ECMs for biomedical applications. Remarkably, on microrod arrays with four times larger feature sizes the fibroblasts were significantly less elongated and their proliferation was strongly reduced.

Original languageEnglish
Pages (from-to)3171-3177
Number of pages7
JournalJournal of Materials Chemistry
Volume20
Issue number16
DOIs
Publication statusPublished - 2010
Externally publishedYes

Keywords

  • TISSUE ENGINEERING SCAFFOLDS
  • NANOFIBERS
  • GROWTH
  • CELLS
  • REPLICATION
  • TOPOGRAPHY
  • TEMPLATES

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