Cellular Localization and Processing of Primary Transcripts of Exonic MicroRNAs

Izabella Slezak-Prochazka, Joost Kluiver, Debora de Jong, Gertrud Kortman, Nancy Halsema, Sibrand Poppema, Bart-Jan Kroesen, Anke van den Berg*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Processing of miRNAs occurs simultaneous with the transcription and splicing of their primary transcripts. For the small subset of exonic miRNAs it is unclear if the unspliced and/or spliced transcripts are used for miRNA biogenesis. We assessed endogenous levels and cellular location of primary transcripts of three exonic miRNAs. The ratio between unspliced and spliced transcripts varied markedly, i.e. >1 for BIC,

Original languageEnglish
Article numbere76647
Number of pages11
JournalPLoS ONE
Volume8
Issue number9
DOIs
Publication statusPublished - 20-Sep-2013

Keywords

  • MICROPROCESSOR COMPLEX
  • HODGKIN LYMPHOMA
  • BURKITT-LYMPHOMA
  • MESSENGER-RNAS
  • NONCODING RNA
  • CELLS
  • EXPRESSION
  • LINES
  • SITES
  • GENE

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