Cellular Senescence and the SenescenceAssociated Secretory Phenotype as Drivers of Skin Photoaging

Eleni Fitsiou, Tanya Pulido, Judith Campisi, Fatouma Alimirah, Marco Demaria*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)

Abstract

Chronic exposure to UVR is known to disrupt tissue homeostasis, accelerate the onset of age-related phenotypes, and increase the risk for skin cancer-a phenomenon defined as photoaging. In this paper, we review the current knowledge on how UV exposure causes cells to prematurely enter cellular senescence. We describe the mechanisms contributing to the accumulation of senescent cells in the skin and how the persistence of cellular senescence can promote impaired regenerative capacity, chronic inflammation, and tumorigenesis associated with photoaging. We conclude by highlighting the potential of senolytic drugs in delaying the onset and progression of age-associated phenotypes in the skin.

Original languageEnglish
Pages (from-to)1119-1126
Number of pages8
JournalJournal of Investigative Dermatology
Volume141
Issue number4
Early online date18-Dec-2020
DOIs
Publication statusPublished - Apr-2021

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