Cerebellar induced differential polyglot aphasia: A neurolinguistic and fMRI study

Peter Marien*, Kim van Dun, Johanna Van Dormael, Dorien Vandenborre, Stefanie Keulen, Mario Manto, Jo Verhoeven, Jubin Abutalebi

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    8 Citations (Scopus)

    Abstract

    Research has shown that linguistic functions in the bilingual brain are subserved by similar neural circuits as in monolinguals, but with extra-activity associated with cognitive and attentional control. Although a role for the right cerebellum in multilingual language processing has recently been acknowledged, a potential role of the left cerebellum remains largely unexplored.

    This paper reports the clinical and fMRI findings in a strongly right-handed (late) multilingual patient who developed differential polyglot aphasia, ataxic dysarthria and a selective decrease in executive function due to an ischemic stroke in the left cerebellum. fMRI revealed that lexical-semantic retrieval in the unaffected L1 was predominantly associated with activations in the left cortical areas (left prefrontal area and left postcentral gyrus), while naming in two affected non-native languages recruited a significantly larger bilateral functional network, including the cerebellum. It is hypothesized that the left cerebellar insult resulted in decreased right prefrontal hemisphere functioning due to a loss of cerebellar impulses through the cerebello-cerebral pathways.

    Original languageEnglish
    Pages (from-to)18-28
    Number of pages11
    JournalBrain and Language
    Volume175
    DOIs
    Publication statusPublished - Dec-2017

    Keywords

    • Cerebellum
    • Polyglot aphasia
    • Bilingualism
    • fMRI
    • Differential recovery
    • LANGUAGE CONTROL
    • BILINGUAL APHASIA
    • SUBCORTICAL APHASIA
    • VISUAL COMPLEXITY
    • IMAGE AGREEMENT
    • NAME AGREEMENT
    • 2ND-LANGUAGE
    • BRAIN
    • REPRESENTATION
    • METAANALYSIS

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