Cerebral autoregulation in pregnancies complicated by diabetes and overweight

Teelkien R. van Veen*, Ronney B. Panerai, Sina Haeri, Paul P. van den Berg, Gerda G. Zeeman, Michael A. Belfort

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)


Aim: The aim of this study was to estimate the impact of diabetes and obesity on cerebral autoregulation in pregnancy.

Methods: Cerebral autoregulation was evaluated in women with gestational diabetes, type 2 diabetes mellitus and/or overweight (body mass index >= 25kgm(-2)) and compared to a cohort of euglycaemic pregnant women. The autoregulation index was calculated using simultaneously recorded cerebral blood flow velocity in the middle cerebral artery and blood pressure. Autoregulation index values of 0 and 9 indicate absent and perfect autoregulation, respectively.

Results: Autoregulation index in women with either diabetes (n=33, 6.6 +/- 1.1) or overweight (n=21, 6.7 +/- 0.6) was not significantly different to that in control patients (n=23, 6.6 +/- 0.8, p=0.96).

Conclusion: Cerebral autoregulation is not impaired in pregnant women who have non-vasculopathic diabetes or overweight. This suggests that the increased risk of pre-eclampsia in diabetic and overweight women is not associated with early impaired cerebral autoregulation.

Original languageEnglish
Pages (from-to)377-380
Number of pages4
JournalDiabetes & Vascular Disease Research
Issue number5
Publication statusPublished - Sep-2015


  • Diabetes
  • overweight
  • pregnancy
  • cerebral autoregulation
  • pre-eclampsia

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