CEREBROVASCULAR COMPLICATIONS OF L-ASPARAGINASE THERAPY IN CHILDREN WITH LEUKEMIA - APHASIA AND OTHER NEUROPSYCHOLOGICAL DEFICITS

A KINGMA; RYJ TAMMINGA; WA KAMPS; R LECOULTRE; RJ SAAN

CEREBROVASCULAR COMPLICATIONS OF L-ASPARAGINASE THERAPY IN CHILDREN WITH LEUKEMIA - APHASIA AND OTHER NEUROPSYCHOLOGICAL DEFICITS

A KINGMA^*, RYJ TAMMINGA, WA KAMPS, R LECOULTRE, RJ SAAN

^*Corresponding author for this work

Faculty of Medical Sciences/UMCG

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

11 Citations (Scopus)

Abstract

Children with acute lymphoblastic leukemia (ALL), treated with L-asparaginase are at risk for cerebral thrombosis or hemorrhage because of coagulation protein deficiencies. The results and the importance of serial neuropsychological examination after such complications in three children with ALL are presented. All patients showed marked aphasia and other cognitive deficits. Recovery was complete in two of three children.

Original language	English
Pages (from-to)	303-309
Number of pages	7
Journal	Pediatric hematology and oncology
Volume	10
Issue number	4
Publication status	Published - 1993

Keywords

APHASIA IN CHILDREN
CEREBROVASCULAR ACCIDENT
L-ASPARAGINASE
ACUTE LYMPHOBLASTIC LEUKEMIA
NEUROPSYCHOLOGICAL DEFICITS
CHILDHOOD

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title = "CEREBROVASCULAR COMPLICATIONS OF L-ASPARAGINASE THERAPY IN CHILDREN WITH LEUKEMIA - APHASIA AND OTHER NEUROPSYCHOLOGICAL DEFICITS",

abstract = "Children with acute lymphoblastic leukemia (ALL), treated with L-asparaginase are at risk for cerebral thrombosis or hemorrhage because of coagulation protein deficiencies. The results and the importance of serial neuropsychological examination after such complications in three children with ALL are presented. All patients showed marked aphasia and other cognitive deficits. Recovery was complete in two of three children.",

keywords = "APHASIA IN CHILDREN, CEREBROVASCULAR ACCIDENT, L-ASPARAGINASE, ACUTE LYMPHOBLASTIC LEUKEMIA, NEUROPSYCHOLOGICAL DEFICITS, CHILDHOOD",

author = "A KINGMA and RYJ TAMMINGA and WA KAMPS and R LECOULTRE and RJ SAAN",

year = "1993",

language = "English",

volume = "10",

pages = "303--309",

journal = "Pediatric hematology and oncology",

issn = "0888-0018",

publisher = "Taylor & Francis Group",

number = "4",

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TY - JOUR

T1 - CEREBROVASCULAR COMPLICATIONS OF L-ASPARAGINASE THERAPY IN CHILDREN WITH LEUKEMIA - APHASIA AND OTHER NEUROPSYCHOLOGICAL DEFICITS

AU - KINGMA, A

AU - TAMMINGA, RYJ

AU - KAMPS, WA

AU - LECOULTRE, R

AU - SAAN, RJ

PY - 1993

Y1 - 1993

N2 - Children with acute lymphoblastic leukemia (ALL), treated with L-asparaginase are at risk for cerebral thrombosis or hemorrhage because of coagulation protein deficiencies. The results and the importance of serial neuropsychological examination after such complications in three children with ALL are presented. All patients showed marked aphasia and other cognitive deficits. Recovery was complete in two of three children.

AB - Children with acute lymphoblastic leukemia (ALL), treated with L-asparaginase are at risk for cerebral thrombosis or hemorrhage because of coagulation protein deficiencies. The results and the importance of serial neuropsychological examination after such complications in three children with ALL are presented. All patients showed marked aphasia and other cognitive deficits. Recovery was complete in two of three children.

KW - APHASIA IN CHILDREN

KW - CEREBROVASCULAR ACCIDENT

KW - L-ASPARAGINASE

KW - ACUTE LYMPHOBLASTIC LEUKEMIA

KW - NEUROPSYCHOLOGICAL DEFICITS

KW - CHILDHOOD

M3 - Comment/Letter to the editor

SN - 0888-0018

VL - 10

SP - 303

EP - 309

JO - Pediatric hematology and oncology

JF - Pediatric hematology and oncology

IS - 4

ER -

CEREBROVASCULAR COMPLICATIONS OF L-ASPARAGINASE THERAPY IN CHILDREN WITH LEUKEMIA - APHASIA AND OTHER NEUROPSYCHOLOGICAL DEFICITS

Abstract

Keywords

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