TY - JOUR
T1 - Challenges and future directions for studying effects of host genetics on the gut microbiome
AU - Sanna, Serena
AU - Kurilshikov, Alexander
AU - van der Graaf, Adriaan
AU - Fu, Jingyuan
AU - Zhernakova, Alexandra
N1 - © 2022. Springer Nature America, Inc.
PY - 2022/2
Y1 - 2022/2
N2 - The human gut microbiome is a complex ecosystem that is involved in its host's metabolism, immunity and health. Although interindividual variations in gut microbial composition are mainly driven by environmental factors, some gut microorganisms are heritable and thus can be influenced by host genetics. In the past 5 years, 12 microbial genome-wide association studies (mbGWAS) with >1,000 participants have been published, yet only a few genetic loci have been consistently confirmed across multiple studies. Here we discuss the state of the art for mbGWAS, focusing on current challenges such as the heterogeneity of microbiome measurements and power issues, and we elaborate on potential future directions for genetic analysis of the microbiome.
AB - The human gut microbiome is a complex ecosystem that is involved in its host's metabolism, immunity and health. Although interindividual variations in gut microbial composition are mainly driven by environmental factors, some gut microorganisms are heritable and thus can be influenced by host genetics. In the past 5 years, 12 microbial genome-wide association studies (mbGWAS) with >1,000 participants have been published, yet only a few genetic loci have been consistently confirmed across multiple studies. Here we discuss the state of the art for mbGWAS, focusing on current challenges such as the heterogeneity of microbiome measurements and power issues, and we elaborate on potential future directions for genetic analysis of the microbiome.
UR - https://rdcu.be/cGiWg
U2 - 10.1038/s41588-021-00983-z
DO - 10.1038/s41588-021-00983-z
M3 - Review article
C2 - 35115688
SN - 1061-4036
SP - 100
EP - 106
JO - Nature genetics
JF - Nature genetics
IS - 2
ER -