Abstract
An acute endolymphatic hydrops was induced by the injection of 1.1 mu l of artificial endolymph into the scala media of guinea pig cochleas. This volume corresponds with an acute endolymphatic hydrops of 23%. During and after the injection, cochlear function was assessed by measuring the 2f(1)-f(2) and f(2)-f(1) distortion products in cochlear microphonics (CMDP) and the 2f(1)-f(2) distortion product otoacoustic emission (DPOAE). A reversible pressure increase of 23 Pa and a relatively stable endocochlear potential (EP) were accompanied by a mean decrease in 2f(1)-f(2) DPOAE of only 3.4 dB. Similarly, the 2f(1)-f(2) CMDP amplitude change was minimal during and after the injection. The only substantial change was measured in the f(2)-f(1) CMDP amplitude. The measured range of distortion amplitudes during an acute endolymphatic hydrops can be related to small changes in the cochlear transducer operating point.
| Original language | English |
|---|---|
| Pages (from-to) | 430-434 |
| Number of pages | 5 |
| Journal | European Archives of Oto-Rhino-Laryngology |
| Volume | 263 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May-2006 |
Keywords
- acute endolymphatic hydrops
- Meniere's disease
- distortion
- cochlear transducer
- operating point
- MENIERES-DISEASE
- INNER-EAR
- ELECTROCOCHLEOGRAPHY
- PRESSURE
- MODEL