Changes of neurohumoral parameters and endothelin-1 in response to exercise in patients with mild to moderate congestive heart failure

S Genth-Zotz; RJ Zotz; M Cobaugh; DJ van Veldhuisen; T Netzer; J Meyer; H Darius

Changes of neurohumoral parameters and endothelin-1 in response to exercise in patients with mild to moderate congestive heart failure

S Genth-Zotz, RJ Zotz, M Cobaugh, DJ van Veldhuisen, T Netzer, J Meyer, H Darius^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Scopus)

Abstract

Plasma endothelin levels are increased in patients with moderate and severe CHF. Conflicting data exist about the endothelin-l (ET) level in patients with mild to moderate CHF and the effect of maximal exercise on plasma ET levels. Methods and results: We determined the plasma levels of ET and various neurohumoral parameters in 93 patients with CHF in functional class II and III of the NYHA classification at rest and after maximal bicycle exercise. Baseline ET level was increased compared to an age-matched healthy volunteer group (6.95+/-0.31 vs 3.29+/-0.17 pg/ml, mean+/-S.E.M, P

Original language	English
Pages (from-to)	137-142
Number of pages	6
Journal	International Journal of Cardiology
Volume	66
Issue number	2
Publication status	Published - 30-Sept-1998

Keywords

neurohumoral activation
endothelin
heart failure
exercise capacity
PLASMA ENDOTHELIN
BLOOD-FLOW

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title = "Changes of neurohumoral parameters and endothelin-1 in response to exercise in patients with mild to moderate congestive heart failure",

abstract = "Plasma endothelin levels are increased in patients with moderate and severe CHF. Conflicting data exist about the endothelin-l (ET) level in patients with mild to moderate CHF and the effect of maximal exercise on plasma ET levels. Methods and results: We determined the plasma levels of ET and various neurohumoral parameters in 93 patients with CHF in functional class II and III of the NYHA classification at rest and after maximal bicycle exercise. Baseline ET level was increased compared to an age-matched healthy volunteer group (6.95+/-0.31 vs 3.29+/-0.17 pg/ml, mean+/-S.E.M, P",

keywords = "neurohumoral activation, endothelin, heart failure, exercise capacity, PLASMA ENDOTHELIN, BLOOD-FLOW",

author = "S Genth-Zotz and RJ Zotz and M Cobaugh and {van Veldhuisen}, DJ and T Netzer and J Meyer and H Darius",

year = "1998",

month = sep,

day = "30",

language = "English",

volume = "66",

pages = "137--142",

journal = "International Journal of Cardiology",

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TY - JOUR

T1 - Changes of neurohumoral parameters and endothelin-1 in response to exercise in patients with mild to moderate congestive heart failure

AU - Genth-Zotz, S

AU - Zotz, RJ

AU - Cobaugh, M

AU - van Veldhuisen, DJ

AU - Netzer, T

AU - Meyer, J

AU - Darius, H

PY - 1998/9/30

Y1 - 1998/9/30

N2 - Plasma endothelin levels are increased in patients with moderate and severe CHF. Conflicting data exist about the endothelin-l (ET) level in patients with mild to moderate CHF and the effect of maximal exercise on plasma ET levels. Methods and results: We determined the plasma levels of ET and various neurohumoral parameters in 93 patients with CHF in functional class II and III of the NYHA classification at rest and after maximal bicycle exercise. Baseline ET level was increased compared to an age-matched healthy volunteer group (6.95+/-0.31 vs 3.29+/-0.17 pg/ml, mean+/-S.E.M, P

AB - Plasma endothelin levels are increased in patients with moderate and severe CHF. Conflicting data exist about the endothelin-l (ET) level in patients with mild to moderate CHF and the effect of maximal exercise on plasma ET levels. Methods and results: We determined the plasma levels of ET and various neurohumoral parameters in 93 patients with CHF in functional class II and III of the NYHA classification at rest and after maximal bicycle exercise. Baseline ET level was increased compared to an age-matched healthy volunteer group (6.95+/-0.31 vs 3.29+/-0.17 pg/ml, mean+/-S.E.M, P

KW - neurohumoral activation

KW - endothelin

KW - heart failure

KW - exercise capacity

KW - PLASMA ENDOTHELIN

KW - BLOOD-FLOW

M3 - Article

SN - 0167-5273

VL - 66

SP - 137

EP - 142

JO - International Journal of Cardiology

JF - International Journal of Cardiology

IS - 2

ER -

Changes of neurohumoral parameters and endothelin-1 in response to exercise in patients with mild to moderate congestive heart failure

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