Characteristics of a new system for monitoring the leakage factor during regional hyperthermic isolated limb perfusion

Roel Wierts*, Johan R. de Jong, Sergiy V. Lazarenko, Anne M. Paans, Rudi A. Dierckx, Antoon M. Willemsen

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    2 Citations (Scopus)

    Abstract

    Rationale A new system is presented and evaluated for real-time monitoring of blood leakage during hyperthermic isolated limb perfusion (HILP) surgery, the Veenstra HILP system. This system incorporates two software models to determine blood leakage: a single-nuclide algorithm and a newly developed dual-nuclide algorithm. The latter algorithm has the advantage that, in principle, it is independent of system sensitivity and thus independent of changes in geometrical efficiency. A physical description of the system is given, together with the required hardware and software specifications.

    Methods In-vitro measurements, corresponding to the intended clinical use, are presented to investigate the relevant performance characteristics of the system: count rate linearity, measurement uncertainty, response time, and accuracy. As the Veenstra HILP system provides the opportunity to use different filter settings and averaging time, the influence of these settings on the time response and measurement uncertainty is described.

    Results Count rate linearity was better than 1% for the count rate domain typically observed during HILP procedures. The response time of the system degrades with increasing total averaging time. In contrast, measurement uncertainty in the blood leakage factor improves with increasing radiotracer count rates and increasing total averaging time. For both blood leakage algorithms, measurement accuracy is better than 1.0 and 1.5%, respectively.

    Conclusion Measurements have shown that the system is well suited for the real-time monitoring of blood leakage during HILP surgery. Furthermore, a good agreement was observed between the theoretical and measured response time and measurement uncertainty. Nucl Med Commun 32: 853-862 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins. Nuclear Medicine Communications 2011, 32: 853-862

    Original languageEnglish
    Pages (from-to)853-862
    Number of pages10
    JournalNuclear Medicine Communications
    Volume32
    Issue number9
    DOIs
    Publication statusPublished - Sep-2011

    Keywords

    • blood leakage
    • chemotherapy
    • isolated limb perfusion
    • monitoring system
    • radiotracer
    • TUMOR-NECROSIS-FACTOR
    • HUMAN SERUM-ALBUMIN
    • FACTOR-ALPHA
    • MELPHALAN
    • GAMMA
    • CHEMOTHERAPY
    • TOXICITY
    • LIVER

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