Charge driven fragmentation of biologically relevant molecules

T.A. Schlathölter; R.A. Hoekstra; R.W.H. Morgenstern

doi:10.1016/j.ijms.2003.12.029

Charge driven fragmentation of biologically relevant molecules

T.A. Schlathölter^*, R.A. Hoekstra, R.W.H. Morgenstern

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

46 Citations (Scopus)

Abstract

A highly charged ion causes ultrastrong electric fields at the location of a close-by target molecule. As a response to those fields, several electrons are removed from the molecule on a very short time-scale. In the subsequent fragmentation process, ions with kinetic energies of a few hundred electron volts are produced. We investigated the interaction of 0.5 MeV Xe25+ with the nucleobases uracil and thymine by means of coincidence time-of-flight spectrometry. Our measurements clearly show that fragment kinetic energies reflect the molecular geometry and contain information on the fragmentation pathways. (C) 2004 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	173-179
Number of pages	7
Journal	International Journal of Mass Spectrometry
Volume	233
Issue number	1-3
DOIs	https://doi.org/10.1016/j.ijms.2003.12.029
Publication status	Published - 15-Apr-2004

Keywords

nucleobases
highly charged ions
time-of-flight spectrometry
COULOMB EXPLOSION
ELECTRON-ATTACHMENT
DNA BASES
EXCITATION
THERAPY
THYMINE
IONS

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Charge driven fragmentation of biologically relevant molecules
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title = "Charge driven fragmentation of biologically relevant molecules",

abstract = "A highly charged ion causes ultrastrong electric fields at the location of a close-by target molecule. As a response to those fields, several electrons are removed from the molecule on a very short time-scale. In the subsequent fragmentation process, ions with kinetic energies of a few hundred electron volts are produced. We investigated the interaction of 0.5 MeV Xe25+ with the nucleobases uracil and thymine by means of coincidence time-of-flight spectrometry. Our measurements clearly show that fragment kinetic energies reflect the molecular geometry and contain information on the fragmentation pathways. (C) 2004 Elsevier B.V. All rights reserved.",

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author = "T.A. Schlath{\"o}lter and R.A. Hoekstra and R.W.H. Morgenstern",

year = "2004",

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doi = "10.1016/j.ijms.2003.12.029",

language = "English",

volume = "233",

pages = "173--179",

journal = "International Journal of Mass Spectrometry",

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T1 - Charge driven fragmentation of biologically relevant molecules

AU - Schlathölter, T.A.

AU - Hoekstra, R.A.

AU - Morgenstern, R.W.H.

PY - 2004/4/15

Y1 - 2004/4/15

N2 - A highly charged ion causes ultrastrong electric fields at the location of a close-by target molecule. As a response to those fields, several electrons are removed from the molecule on a very short time-scale. In the subsequent fragmentation process, ions with kinetic energies of a few hundred electron volts are produced. We investigated the interaction of 0.5 MeV Xe25+ with the nucleobases uracil and thymine by means of coincidence time-of-flight spectrometry. Our measurements clearly show that fragment kinetic energies reflect the molecular geometry and contain information on the fragmentation pathways. (C) 2004 Elsevier B.V. All rights reserved.

AB - A highly charged ion causes ultrastrong electric fields at the location of a close-by target molecule. As a response to those fields, several electrons are removed from the molecule on a very short time-scale. In the subsequent fragmentation process, ions with kinetic energies of a few hundred electron volts are produced. We investigated the interaction of 0.5 MeV Xe25+ with the nucleobases uracil and thymine by means of coincidence time-of-flight spectrometry. Our measurements clearly show that fragment kinetic energies reflect the molecular geometry and contain information on the fragmentation pathways. (C) 2004 Elsevier B.V. All rights reserved.

KW - nucleobases

KW - highly charged ions

KW - time-of-flight spectrometry

KW - COULOMB EXPLOSION

KW - ELECTRON-ATTACHMENT

KW - DNA BASES

KW - EXCITATION

KW - THERAPY

KW - THYMINE

KW - IONS

U2 - 10.1016/j.ijms.2003.12.029

DO - 10.1016/j.ijms.2003.12.029

M3 - Article

SN - 1387-3806

VL - 233

SP - 173

EP - 179

JO - International Journal of Mass Spectrometry

JF - International Journal of Mass Spectrometry

IS - 1-3

ER -

Charge driven fragmentation of biologically relevant molecules

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Keywords

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