Chemical approaches for quantitative proteomics

Xiaobo Tian

Research output: ThesisThesis fully internal (DIV)

28 Downloads (Pure)

Abstract

Xiaobo focuses on developing novel isotope labeling-based tags for quantitative proteomics along two lines of research: (1) In data-dependent acquisition (DDA) mode, eliminating the ratio distortion caused by peptide cofragmentation and increasing the multiplexing capacity. (2) In data-independent acquisition (DIA) mode, achieving multiplexed quantification with general DIA LC-MS settings. The representative work, Ac-IP tag that specifically suitable for the multiplexing in DIA mode, attracted much attention from peers.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • University of Groningen
Supervisors/Advisors
  • Bischoff, Rainer, Supervisor
  • Permentier, Hjalmar, Co-supervisor
Award date24-Sep-2021
Place of Publication[Groningen]
Publisher
DOIs
Publication statusPublished - 2021

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