Chemically Engineered Immune Cell-Derived Microrobots and Biomimetic Nanoparticles: Emerging Biodiagnostic and Therapeutic Tools

Leila Pourtalebi Jahromi, Mohammad-Ali Shahbazi*, Aziz Maleki, Amir Azadi*, Helder A. Santos*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

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Abstract

Over the past decades, considerable attention has been dedicated to the exploitation of diverse immune cells as therapeutic and/or diagnostic cell-based microrobots for hard-to-treat disorders. To date, a plethora of therapeutics based on alive immune cells, surface-engineered immune cells, immunocytes' cell membranes, leukocyte-derived extracellular vesicles or exosomes, and artificial immune cells have been investigated and a few have been introduced into the market. These systems take advantage of the unique characteristics and functions of immune cells, including their presence in circulating blood and various tissues, complex crosstalk properties, high affinity to different self and foreign markers, unique potential of their on-demand navigation and activity, production of a variety of chemokines/cytokines, as well as being cytotoxic in particular conditions. Here, the latest progress in the development of engineered therapeutics and diagnostics inspired by immune cells to ameliorate cancer, inflammatory conditions, autoimmune diseases, neurodegenerative disorders, cardiovascular complications, and infectious diseases is reviewed, and finally, the perspective for their clinical application is delineated.
Original languageEnglish
Article number2002499
Number of pages70
JournalAdvanced science
Volume8
Issue number8
DOIs
Publication statusPublished - 21-Apr-2021
Externally publishedYes

Keywords

  • artificial dendritic cell and extracellular vesicle
  • biomimetic drug delivery
  • engineered immune cell
  • immune cell membrane
  • nanomedicine
  • ANTIGEN-PRESENTING CELLS
  • NATURAL-KILLER-CELLS
  • DRUG-DELIVERY-SYSTEMS
  • MEMBRANE-CAMOUFLAGED NANOPARTICLES
  • MACROPHAGE-MEDIATED DELIVERY
  • ISCHEMIA-REPERFUSION INJURY
  • DENDRITIC CELLS
  • EXTRACELLULAR VESICLES
  • T-CELLS
  • PHOTOTHERMAL THERAPY
  • 116 Chemical sciences
  • 318 Medical biotechnology
  • 221 Nano-technology
  • 317 Pharmacy

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