Chemically-stabilized allosteric modulators of leucine-rich repeat kinase 2 (lrrk2)

Eileen Kennedy; Arjan Kortholt; Leah G Helton

Chemically-stabilized allosteric modulators of leucine-rich repeat kinase 2 (lrrk2)

Eileen Kennedy (Inventor), Arjan Kortholt (Inventor), Leah G Helton (Inventor)

Cell Biochemistry

Research output: Patent

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Abstract

The present disclosure describes synthetic polypeptides for the inhibition or modulation of the activity of leucine-rich repeat kinase 2 (LRRK2) along with methods of using the same in the treatment of medical conditions, for example neurological diseases or disorders.

Original language	English
Patent number	WO2021173802
Priority date	25/02/2020
Filing date	25/02/2021
Publication status	Published - 2-Sept-2021

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title = "Chemically-stabilized allosteric modulators of leucine-rich repeat kinase 2 (lrrk2)",

abstract = "The present disclosure describes synthetic polypeptides for the inhibition or modulation of the activity of leucine-rich repeat kinase 2 (LRRK2) along with methods of using the same in the treatment of medical conditions, for example neurological diseases or disorders.",

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AU - Kortholt, Arjan

AU - Helton, Leah G

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N2 - The present disclosure describes synthetic polypeptides for the inhibition or modulation of the activity of leucine-rich repeat kinase 2 (LRRK2) along with methods of using the same in the treatment of medical conditions, for example neurological diseases or disorders.

AB - The present disclosure describes synthetic polypeptides for the inhibition or modulation of the activity of leucine-rich repeat kinase 2 (LRRK2) along with methods of using the same in the treatment of medical conditions, for example neurological diseases or disorders.

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Chemically-stabilized allosteric modulators of leucine-rich repeat kinase 2 (lrrk2)

Abstract

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