Abstract
The potential of chemometrics for drug impurity profiling has been examined in this thesis. Generally, various hyphenated methods are used for the analysis of drug sub¬stance and product in order to enable the identification and quantification of impuri¬ties. chemometrics can be used to enhance the information content of results from hyphenated methods. Optimisation may be used to improve the chromatographic and electrophoretic separation, while (augmented) curve resolution may be used to extract as much information as possible from one or more of the matrices that are obtained.
| Original language | English |
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| Qualification | Doctor of Philosophy |
| Supervisors/Advisors |
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| Publisher | |
| Publication status | Published - 2008 |
Keywords
- Proefschriften (vorm)
- Curve fitting
- elektroforese, Multivariate analyse, Empirische processen, N
- Chemometrie, Optimaliseren, Capillaire
- farmacologie (geneeskunde)
- mathematische en statistische methoden van de scheikunde