Abstract
The literature on enantioselective liquid-liquid extraction (ELLE) spans more than half a century of research. Nonetheless, a comprehensive overview has not appeared during the past few decades. Enantioselective liquid-liquid extraction is a technology of interest for a wide range of chemists and chemical engineers in the fields of fine chemicals, pharmaceuticals, agrochemicals, fragrances and foods. In this review the principles and advances of resolution through enantioselective liquid-liquid extraction are discussed, starting with an introduction on the principles of enantioselective liquid-liquid extraction including host-guest chemistry, extraction and phase transfer mechanisms, and multistage liquid-liquid extraction processing. Then the literature on enantioselective liquid-liquid extraction systems is reviewed, structured on extractant classes. The following extractant classes are considered: crown ether based extractants, metal complexes and metalloids, extractants based on tartrates, and a final section with all other types of chiral extractants.
| Original language | English |
|---|---|
| Pages (from-to) | 36-51 |
| Number of pages | 16 |
| Journal | Organic & Biomolecular Chemistry |
| Volume | 9 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2011 |
Keywords
- Molecular Conformation
- Models, Molecular
- stereoisomerism
- phase transition
- conformation
- chemical structure
- article
- Liquids
- Solvent extraction
- Metal complexes
- Indicators (chemical)
- Fragrances
- Ethers
- Crown ethers
- Chirality
- Chemical contamination
- Agricultural chemicals
- Phase transfer
- Hostguest chemistry
- Liquid-liquid extraction
- Fine Chemicals
- Extractants
- Enantioselective
- Chiral separations
- Chemical engineers