Cholic acid is accumulated spontaneously, driven by membrane Delta pH, in many lactobacilli

P Kurdi, HW van Veen, H Tanaka, [No Value] Mierau, WN Konings, GW Tannock, F Tomita, A Yokota*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

48 Citations (Scopus)

Abstract

Many lactobacilli from various origins were found to apparently lack cholic acid extrusion activity. Cholic acid was accumulated spontaneously, driven by the transmembrane proton gradient. Accumulation is a newly identified kind of interaction between intestinal microbes and unconjugated bile acids and is different from extrusion and modification, which have been described previously.

Original languageEnglish
Pages (from-to)6525-6528
Number of pages4
JournalJournal of Bacteriology
Volume182
Issue number22
Publication statusPublished - Nov-2000

Keywords

  • NEISSERIA-GONORRHOEAE
  • TRANSPORT
  • BACTERIA
  • PROTEIN
  • EFFLUX
  • SYSTEM

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