Cholinotoxic effects of β-amyloid(1-42) peptide on cortical projections of the rat nucleus basalis magnocellularis

Tibor Harkany; Zsolt Lengyel; Katalin Soós; Botond Penke; Paul G.M. Luiten; Karoly Gulya

Cholinotoxic effects of β-amyloid(1-42) peptide on cortical projections of the rat nucleus basalis magnocellularis

Tibor Harkany
, Zsolt Lengyel
, Katalin Soós
, Botond Penke
, Paul G.M. Luiten
, Karoly Gulya

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Abstract

β-Amyloid(1-42) peptide (βAP) was injected into the right nucleus basalis magnocellularis (nbm) of rats. After a 14-day survival time, the acetylcholinesterase and choline acetyltransferase activities and the number of muscarinic receptors were found biochemically to be significantly reduced in the ipsilateral frontal cortices. Confirmation of these data with silver staining also revealed degeneration of the projective fibers of the nbm to the frontal cortex. These results demonstrate the cholinotoxicity of βAP in an in vivo animal model.

Original language	English
Pages (from-to)	71-75
Number of pages	5
Journal	Brain Research
Volume	695
Publication status	Published - 1995

Keywords

Cholinotoxicity
Cholinergic system
Frontal cortex
Nucleus basalis magnocellularis
β-Amyloid(1-42) peptide

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@article{70b6f49301cc404daa06ef79a87ba073,

title = "Cholinotoxic effects of β-amyloid(1-42) peptide on cortical projections of the rat nucleus basalis magnocellularis",

abstract = "β-Amyloid(1-42) peptide (βAP) was injected into the right nucleus basalis magnocellularis (nbm) of rats. After a 14-day survival time, the acetylcholinesterase and choline acetyltransferase activities and the number of muscarinic receptors were found biochemically to be significantly reduced in the ipsilateral frontal cortices. Confirmation of these data with silver staining also revealed degeneration of the projective fibers of the nbm to the frontal cortex. These results demonstrate the cholinotoxicity of βAP in an in vivo animal model.",

keywords = "Cholinotoxicity, Cholinergic system, Frontal cortex, Nucleus basalis magnocellularis, β-Amyloid(1-42) peptide",

author = "Tibor Harkany and Zsolt Lengyel and Katalin So{\'o}s and Botond Penke and Luiten, \{Paul G.M.\} and Karoly Gulya",

note = "Relation: http://www.rug.nl/fwn/onderzoek/programmas/cbn/index Rights: University of Groningen, Centre for Behaviour and Neurosciences",

year = "1995",

language = "English",

volume = "695",

pages = "71--75",

journal = "Brain Research",

issn = "0006-8993",

publisher = "ELSEVIER SCIENCE BV",

}

TY - JOUR

T1 - Cholinotoxic effects of β-amyloid(1-42) peptide on cortical projections of the rat nucleus basalis magnocellularis

AU - Harkany, Tibor

AU - Lengyel, Zsolt

AU - Soós, Katalin

AU - Penke, Botond

AU - Luiten, Paul G.M.

AU - Gulya, Karoly

N1 - Relation: http://www.rug.nl/fwn/onderzoek/programmas/cbn/index Rights: University of Groningen, Centre for Behaviour and Neurosciences

PY - 1995

Y1 - 1995

N2 - β-Amyloid(1-42) peptide (βAP) was injected into the right nucleus basalis magnocellularis (nbm) of rats. After a 14-day survival time, the acetylcholinesterase and choline acetyltransferase activities and the number of muscarinic receptors were found biochemically to be significantly reduced in the ipsilateral frontal cortices. Confirmation of these data with silver staining also revealed degeneration of the projective fibers of the nbm to the frontal cortex. These results demonstrate the cholinotoxicity of βAP in an in vivo animal model.

AB - β-Amyloid(1-42) peptide (βAP) was injected into the right nucleus basalis magnocellularis (nbm) of rats. After a 14-day survival time, the acetylcholinesterase and choline acetyltransferase activities and the number of muscarinic receptors were found biochemically to be significantly reduced in the ipsilateral frontal cortices. Confirmation of these data with silver staining also revealed degeneration of the projective fibers of the nbm to the frontal cortex. These results demonstrate the cholinotoxicity of βAP in an in vivo animal model.

KW - Cholinotoxicity

KW - Cholinergic system

KW - Frontal cortex

KW - Nucleus basalis magnocellularis

KW - β-Amyloid(1-42) peptide

M3 - Article

SN - 0006-8993

VL - 695

SP - 71

EP - 75

JO - Brain Research

JF - Brain Research

ER -

Cholinotoxic effects of β-amyloid(1-42) peptide on cortical projections of the rat nucleus basalis magnocellularis

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