Chromanol compounds for treatment of heart failure

Robert Henk Henning; Adrianus Cornelis van der Graaf; Guido Krenning; Lucas Moritz Wiggenhauser

Chromanol compounds for treatment of heart failure

Robert Henk Henning (Inventor), Adrianus Cornelis van der Graaf (Inventor), Guido Krenning (Inventor), Lucas Moritz Wiggenhauser (Inventor)

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Abstract

The invention relates to certain chromanol, quinone or hydroquinone compounds and derivatives thereof for treatment of heart failure with reduced ejection fraction (HFrEF). Specifically, the present invention relates to chromanol compounds chosen from S-(6-hydroxy-2,5,7,8-tetramethylchroman-2yl)(piperazin-1-yl)methanone and S-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)(4-(2-hydroxyethyl)piperazin-1-yl)methanone, and pharmaceutically acceptable salts thereof.

Original language	English
Patent number	WO2022058620
Priority date	21/09/2020
Filing date	21/09/2021
Publication status	Published - 24-Mar-2022

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title = "Chromanol compounds for treatment of heart failure",

abstract = "The invention relates to certain chromanol, quinone or hydroquinone compounds and derivatives thereof for treatment of heart failure with reduced ejection fraction (HFrEF). Specifically, the present invention relates to chromanol compounds chosen from S-(6-hydroxy-2,5,7,8-tetramethylchroman-2yl)(piperazin-1-yl)methanone and S-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)(4-(2-hydroxyethyl)piperazin-1-yl)methanone, and pharmaceutically acceptable salts thereof.",

author = "Henning, {Robert Henk} and {van der Graaf}, {Adrianus Cornelis} and Guido Krenning and Wiggenhauser, {Lucas Moritz}",

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TY - PAT

T1 - Chromanol compounds for treatment of heart failure

AU - Henning, Robert Henk

AU - van der Graaf, Adrianus Cornelis

AU - Krenning, Guido

AU - Wiggenhauser, Lucas Moritz

PY - 2022/3/24

Y1 - 2022/3/24

N2 - The invention relates to certain chromanol, quinone or hydroquinone compounds and derivatives thereof for treatment of heart failure with reduced ejection fraction (HFrEF). Specifically, the present invention relates to chromanol compounds chosen from S-(6-hydroxy-2,5,7,8-tetramethylchroman-2yl)(piperazin-1-yl)methanone and S-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)(4-(2-hydroxyethyl)piperazin-1-yl)methanone, and pharmaceutically acceptable salts thereof.

AB - The invention relates to certain chromanol, quinone or hydroquinone compounds and derivatives thereof for treatment of heart failure with reduced ejection fraction (HFrEF). Specifically, the present invention relates to chromanol compounds chosen from S-(6-hydroxy-2,5,7,8-tetramethylchroman-2yl)(piperazin-1-yl)methanone and S-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)(4-(2-hydroxyethyl)piperazin-1-yl)methanone, and pharmaceutically acceptable salts thereof.

M3 - Patent

M1 - WO2022058620

Y2 - 2021/09/21

ER -