Chromosomal abnormalities in non-neoplastic renal tissue

E vandenBerg*, T Dijkhuizen, S Storkel, WM Molenaar, B deJong

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    21 Citations (Scopus)

    Abstract

    Chromosome aberrations were studied in short-term cultures of non-neoplastic renal tissue and tumor tissue in 60 patients, 41 male and 19 female, with renal cell cancer (RCC), and in normal renal parenchyma from two cases, one male and one female, at autopsy with non-kidney related disease. Cytogenetic analysis of the non-neoplastic renal tissue from the patents with RCC revealed clonal chromosome aberrations in 32 of 60 (53%) cases: -Y, +Y, +X, +5, +7, +10, +12, +13, +18, +21, and del(9)(q12). In all other cases, non-clonal numerical and structural chromosome aberrations were observed, except for three cases of culture failure. Forty-two cases of RCC yielded clonal chromosomal abnormalities. Trisomy 7 was present in 23 cases, loss of Y in 14, trisomy 5 and 12 in three, trisomy 18 in two cases, and trisomy 10 in one case. Clonal chromosomal anomalies found in two cases from kidneys without neoplasia were trisomy 7, trisomy 12, and trisomy 18 in one case, and monosomy of chromosome 15 in the other. The proportion of aberrant cells in both cases (with clonal and non-clonal aberrations) was, on average, 24%. Apparently, chromosomal abnormalities only play a role in the process of oncogenesis when they are in the appropriate stage and lineage of differentiation.

    Original languageEnglish
    Pages (from-to)152-154
    Number of pages3
    JournalCancer Genetics and Cytogenetics
    Volume85
    Issue number2
    Publication statusPublished - Dec-1995

    Keywords

    • NORMAL KIDNEY TISSUE
    • CELL CARCINOMA
    • TUMORS
    • TRISOMY-7
    • ABERRATIONS

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