Chronic kidney disease: Insights from social and genetic epidemiology

    Research output: ThesisThesis fully internal (DIV)

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    Abstract

    Chronic kidney disease is a major global health burden, caused by the complex interplay between environmental and genetic factors. The results in this thesis provide valuable insights into these causes. First, I corroborate the existence of socioeconomic disparities in kidney disease, as those with lower education seem to have higher rates of chronic kidney disease and faster rates of kidney function decline. Second, those with a positive family history have a threefold higher risk of having chronic kidney disease, and there is strong evidence for a genetic component to kidney function and kidney damage. Third, genetic risk of chronic kidney disease may be offset by higher socioeconomic status. Finally, educational level may not be the main driver of socioeconomic disparities in chronic kidney disease, as the genetic evidence for a causal effect of educational level is inconclusive.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    Supervisors/Advisors
    • Snieder, Harold, Supervisor
    • Gansevoort, Ron, Supervisor
    • Bultmann, Ute, Supervisor
    Award date7-Oct-2020
    Place of Publication[Groningen]
    Publisher
    Print ISBNs978-94-034-2609-9
    Electronic ISBNs978-94-034-2608-2
    DOIs
    Publication statusPublished - 2020

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