Chronic lymphocytic leukaemia: A review of the immuno-architecture

S Rosati*, PM Kluin

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

11 Citations (Scopus)

Abstract

Immunophenotyping of B cell chronic lymphocytic leukaemia (B-CLL) is usually performed by flow cytometry on cell suspensions obtained from peripheral blood, bone marrow or biopsied tissue. Immunohistochemical analysis on routine sections is less commonly performed; however, this approach allows the pathologist and the researcher to appreciate the immuno-architecture of the involved tissues and to gain insight into some of the events that influence the biology of the disease. in this review the authors focus on the following issues: immuno-architecture of the proliferation centres, expression of CD23, MUM1/IRF-4 and cyclin D1, tyrosine phosphorylation and detection of the ZAP-70 kinase. Whenever possible, an attempt is made to interpret the immunohistochemical findings from a functional point of view.

Original languageEnglish
Title of host publicationChronic lymphocytic leukemia
Place of PublicationBerlin
PublisherSpringer
Pages90-107
Number of pages18
Volume294
ISBN (Electronic)978-3-540-29933-2
ISBN (Print)978-3-540-25279-5
DOIs
Publication statusPublished - 2005

Publication series

NameCURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY
PublisherSPRINGER-VERLAG BERLIN
Volume294
ISSN (Print)0070-217X

Keywords

  • MANTLE CELL LYMPHOMA
  • B-CELL
  • ZAP-70 EXPRESSION
  • TRANSCRIPTION FACTOR
  • MONOCLONAL-ANTIBODY
  • CD23 ISOFORMS
  • NITRIC-OXIDE
  • PLASMA-CELLS
  • T-CELLS
  • GENE

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