Chronic stimulation of the subthalamic nucleus increases daily on-time without dyskinesia in advanced Parkinson's disease

A. T. Portman; T. van Laar; M. J. Staal; A. W.F. Rutgers; H. L. Journee; K. L. Leenders

doi:10.1016/j.parkreldis.2005.15.007

Chronic stimulation of the subthalamic nucleus increases daily on-time without dyskinesia in advanced Parkinson's disease

A. T. Portman
, T. van Laar
, M. J. Staal
, A. W.F. Rutgers
, H. L. Journee
, K. L. Leenders

Research output: Contribution to journal › Article › Academic › peer-review

11 Citations (Scopus)

Abstract

We assessed the efficacy of chronic stimulation of the subthalamic nucleus (STN-DBS) in 20 patients with Parkinson's disease (PD) by means of clinical assessments and patient diaries 12 months after surgery.

STN-DBS reduced the UPDRS part III off-medication score by 33%, and successively improved complete daily on-time without dyskinesia at 12 months significantly.

In conclusion, our study demonstrates the efficacy of chronic STN-DBS on motor features in a selected population of advanced PD patients. In addition to clinical assessments, patients' diaries serve as an essential tool to evaluate the functional motor status after STN-DBS. (c) 2006 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	143-148
Number of pages	6
Journal	Parkinsonism & Related Disorders
Volume	12
Issue number	3
DOIs	https://doi.org/10.1016/j.parkreldis.2005.15.007
Publication status	Published - Apr-2006

Keywords

Parkinson's disease
neurosurgery
subthalamic nucleus
on-time
patient diary
DEEP-BRAIN-STIMULATION
2-YEAR FOLLOW-UP
PD
LEVODOPA
MOOD
DBS

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Chronic stimulation of the subthalamic nucleus increases daily on-time without dyskinesia in advanced Parkinson's disease
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@article{90711966e5ad404a8f5f062fa281c129,

title = "Chronic stimulation of the subthalamic nucleus increases daily on-time without dyskinesia in advanced Parkinson's disease",

abstract = "We assessed the efficacy of chronic stimulation of the subthalamic nucleus (STN-DBS) in 20 patients with Parkinson's disease (PD) by means of clinical assessments and patient diaries 12 months after surgery.STN-DBS reduced the UPDRS part III off-medication score by 33\%, and successively improved complete daily on-time without dyskinesia at 12 months significantly.In conclusion, our study demonstrates the efficacy of chronic STN-DBS on motor features in a selected population of advanced PD patients. In addition to clinical assessments, patients' diaries serve as an essential tool to evaluate the functional motor status after STN-DBS. (c) 2006 Elsevier Ltd. All rights reserved.",

keywords = "Parkinson's disease, neurosurgery, subthalamic nucleus, on-time, patient diary, DEEP-BRAIN-STIMULATION, 2-YEAR FOLLOW-UP, PD, LEVODOPA, MOOD, DBS",

author = "Portman, \{A. T.\} and Laar, \{T. van\} and Staal, \{M. J.\} and Rutgers, \{A. W.F.\} and Journee, \{H. L.\} and Leenders, \{K. L.\}",

year = "2006",

month = apr,

doi = "10.1016/j.parkreldis.2005.15.007",

language = "English",

volume = "12",

pages = "143--148",

journal = "Parkinsonism \& Related Disorders",

issn = "1353-8020",

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T1 - Chronic stimulation of the subthalamic nucleus increases daily on-time without dyskinesia in advanced Parkinson's disease

AU - Portman, A. T.

AU - Laar, T. van

AU - Staal, M. J.

AU - Rutgers, A. W.F.

AU - Journee, H. L.

AU - Leenders, K. L.

PY - 2006/4

Y1 - 2006/4

N2 - We assessed the efficacy of chronic stimulation of the subthalamic nucleus (STN-DBS) in 20 patients with Parkinson's disease (PD) by means of clinical assessments and patient diaries 12 months after surgery.STN-DBS reduced the UPDRS part III off-medication score by 33%, and successively improved complete daily on-time without dyskinesia at 12 months significantly.In conclusion, our study demonstrates the efficacy of chronic STN-DBS on motor features in a selected population of advanced PD patients. In addition to clinical assessments, patients' diaries serve as an essential tool to evaluate the functional motor status after STN-DBS. (c) 2006 Elsevier Ltd. All rights reserved.

AB - We assessed the efficacy of chronic stimulation of the subthalamic nucleus (STN-DBS) in 20 patients with Parkinson's disease (PD) by means of clinical assessments and patient diaries 12 months after surgery.STN-DBS reduced the UPDRS part III off-medication score by 33%, and successively improved complete daily on-time without dyskinesia at 12 months significantly.In conclusion, our study demonstrates the efficacy of chronic STN-DBS on motor features in a selected population of advanced PD patients. In addition to clinical assessments, patients' diaries serve as an essential tool to evaluate the functional motor status after STN-DBS. (c) 2006 Elsevier Ltd. All rights reserved.

KW - Parkinson's disease

KW - neurosurgery

KW - subthalamic nucleus

KW - on-time

KW - patient diary

KW - DEEP-BRAIN-STIMULATION

KW - 2-YEAR FOLLOW-UP

KW - PD

KW - LEVODOPA

KW - MOOD

KW - DBS

U2 - 10.1016/j.parkreldis.2005.15.007

DO - 10.1016/j.parkreldis.2005.15.007

M3 - Article

SN - 1353-8020

VL - 12

SP - 143

EP - 148

JO - Parkinsonism & Related Disorders

JF - Parkinsonism & Related Disorders

IS - 3

ER -

Chronic stimulation of the subthalamic nucleus increases daily on-time without dyskinesia in advanced Parkinson's disease

Abstract

Keywords

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