Cigarette smoking and progression in multiple sclerosis

Marcus Koch; Annemarie van Harten; Maarten Uyttenboogaart; Jacques De Keyser

doi:10.1212/01.wnl.0000277658.78381.db

Cigarette smoking and progression in multiple sclerosis

Marcus Koch^*, Annemarie van Harten, Maarten Uyttenboogaart, Jacques De Keyser

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

81 Citations (Scopus)

Abstract

Objective: To investigate the influence of cigarette smoking on progression and disability accumulation in multiple sclerosis ( MS).

Methods: Information on past and present smoking of 364 patients with MS was obtained through a structured questionnaire survey. We used Kaplan-Meier analyses and Cox regression models to evaluate the influence of smoking on the development and age at onset of secondary progression, on the age at onset of progression in patients with primary progressive MS, and on the time from disease onset to Expanded Disability Status Scale ( EDSS) scores 4.0 and 6.0 in all patients. We also investigated the correlation between smoked pack-years and EDSS scores and the rate of progression as measured with the Multiple Sclerosis Severity Score.

Results: We found no significant associations between cigarette smoking and any of the used measures.

Conclusion: Our data suggest that cigarette smoking has no influence on disease progression or accumulation of disability in multiple sclerosis.

Original language	English
Pages (from-to)	1515-1520
Number of pages	6
Journal	Neurology
Volume	69
Issue number	15
DOIs	https://doi.org/10.1212/01.wnl.0000277658.78381.db
Publication status	Published - 9-Oct-2007

Keywords

NATURAL-HISTORY
DISEASE
PHASE

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@article{f40261c8acc24357a8635459d28dbf55,

title = "Cigarette smoking and progression in multiple sclerosis",

abstract = "Objective: To investigate the influence of cigarette smoking on progression and disability accumulation in multiple sclerosis ( MS).Methods: Information on past and present smoking of 364 patients with MS was obtained through a structured questionnaire survey. We used Kaplan-Meier analyses and Cox regression models to evaluate the influence of smoking on the development and age at onset of secondary progression, on the age at onset of progression in patients with primary progressive MS, and on the time from disease onset to Expanded Disability Status Scale ( EDSS) scores 4.0 and 6.0 in all patients. We also investigated the correlation between smoked pack-years and EDSS scores and the rate of progression as measured with the Multiple Sclerosis Severity Score.Results: We found no significant associations between cigarette smoking and any of the used measures.Conclusion: Our data suggest that cigarette smoking has no influence on disease progression or accumulation of disability in multiple sclerosis.",

keywords = "NATURAL-HISTORY, DISEASE, PHASE",

author = "Marcus Koch and {van Harten}, Annemarie and Maarten Uyttenboogaart and {De Keyser}, Jacques",

year = "2007",

month = oct,

day = "9",

doi = "10.1212/01.wnl.0000277658.78381.db",

language = "English",

volume = "69",

pages = "1515--1520",

journal = "Neurology",

issn = "0028-3878",

publisher = "LIPPINCOTT WILLIAMS & WILKINS",

number = "15",

}

TY - JOUR

T1 - Cigarette smoking and progression in multiple sclerosis

AU - Koch, Marcus

AU - van Harten, Annemarie

AU - Uyttenboogaart, Maarten

AU - De Keyser, Jacques

PY - 2007/10/9

Y1 - 2007/10/9

N2 - Objective: To investigate the influence of cigarette smoking on progression and disability accumulation in multiple sclerosis ( MS).Methods: Information on past and present smoking of 364 patients with MS was obtained through a structured questionnaire survey. We used Kaplan-Meier analyses and Cox regression models to evaluate the influence of smoking on the development and age at onset of secondary progression, on the age at onset of progression in patients with primary progressive MS, and on the time from disease onset to Expanded Disability Status Scale ( EDSS) scores 4.0 and 6.0 in all patients. We also investigated the correlation between smoked pack-years and EDSS scores and the rate of progression as measured with the Multiple Sclerosis Severity Score.Results: We found no significant associations between cigarette smoking and any of the used measures.Conclusion: Our data suggest that cigarette smoking has no influence on disease progression or accumulation of disability in multiple sclerosis.

AB - Objective: To investigate the influence of cigarette smoking on progression and disability accumulation in multiple sclerosis ( MS).Methods: Information on past and present smoking of 364 patients with MS was obtained through a structured questionnaire survey. We used Kaplan-Meier analyses and Cox regression models to evaluate the influence of smoking on the development and age at onset of secondary progression, on the age at onset of progression in patients with primary progressive MS, and on the time from disease onset to Expanded Disability Status Scale ( EDSS) scores 4.0 and 6.0 in all patients. We also investigated the correlation between smoked pack-years and EDSS scores and the rate of progression as measured with the Multiple Sclerosis Severity Score.Results: We found no significant associations between cigarette smoking and any of the used measures.Conclusion: Our data suggest that cigarette smoking has no influence on disease progression or accumulation of disability in multiple sclerosis.

KW - NATURAL-HISTORY

KW - DISEASE

KW - PHASE

U2 - 10.1212/01.wnl.0000277658.78381.db

DO - 10.1212/01.wnl.0000277658.78381.db

M3 - Article

C2 - 17923613

SN - 0028-3878

VL - 69

SP - 1515

EP - 1520

JO - Neurology

JF - Neurology

IS - 15

ER -

Cigarette smoking and progression in multiple sclerosis

Abstract

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