Circadian regulation of olfaction and an evolutionarily conserved, nontranscriptional marker in Caenorhabditis elegans

Maria Olmedo*, John S. O'Neill, Rachel S. Edgar, Utham K. Valekunja, Akhilesh B. Reddy, Martha Merrow

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

35 Citations (Scopus)
219 Downloads (Pure)

Abstract

Circadian clocks provide a temporal structure to processes from gene expression to behavior in organisms from all phyla. Most clocks are synchronized to the environment by alternations of light and dark. However, many organisms experience only muted daily environmental cycles due to their lightless spatial niches (e.g., caves or soil). This has led to speculation that they may dispense with the daily clock. However, recent reports contradict this notion, showing various behavioral and molecular rhythms in Caenorhabditis elegans and in blind cave fish. Based on the ecology of nematodes, we applied low-amplitude temperature cycles to synchronize populations of animals through development. This entrainment regime reveals rhythms on multiple levels: in olfactory cued behavior, in RNA and protein abundance, and in the oxidation state of a broadly conserved peroxiredoxin protein. Our work links the nematode clock with that of other clock model systems; it also emphasizes the importance of daily rhythms in sensory functions that are likely to impact on organism fitness and population structure.

Original languageEnglish
Pages (from-to)20479-20484
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume109
Issue number50
DOIs
Publication statusPublished - 11-Dec-2012

Keywords

  • chronobiology
  • circadian rhythm
  • lin-42
  • 1-octanol
  • G protein-coupled receptor kinase
  • C-ELEGANS
  • DAILY RHYTHMS
  • CLOCK
  • RESPONSES
  • CHANNELS
  • GENES
  • LIGHT
  • TEMPERATURE
  • ENTRAINMENT
  • RECEPTORS

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