Circular RNAs: Biogenesis, Mechanism, and Function in Human Cancers

Xing Zhao; Yujie Cai; Jianzhen Xu

doi:10.3390/ijms20163926

Circular RNAs: Biogenesis, Mechanism, and Function in Human Cancers

Xing Zhao
, Yujie Cai
, Jianzhen Xu^*

^*Corresponding author for this work

Faculty of Medical Sciences/UMCG

Research output: Contribution to journal › Review article › peer-review

207 Citations (Scopus)

237 Downloads (Pure)

Abstract

CircRNAs are a class of noncoding RNA species with a circular configuration that is formed by either typical spliceosome-mediated or lariat-type splicing. The expression of circRNAs is usually abnormal in many cancers. Several circRNAs have been demonstrated to play important roles in carcinogenesis. In this review, we will first provide an introduction of circRNAs biogenesis, especially the regulation of circRNA by RNA-binding proteins, then we will focus on the recent findings of circRNA molecular mechanisms and functions in cancer development. Finally, some open questions are also discussed.

Original language	English
Article number	3926
Number of pages	13
Journal	International Journal of Molecular Sciences
Volume	20
Issue number	16
DOIs	https://doi.org/10.3390/ijms20163926
Publication status	Published - 13-Aug-2019

Keywords

circRNAs
carcinogenesis
biogenesis
RNA-binding protein
flanking introns
genomic alternation
LANDSCAPE
CIRCHIPK3
PROTEINS
MICRORNA
ABUNDANT
REVEALS
MAP

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Circular RNAs: Biogenesis, Mechanism, and Function in Human CancersFinal publisher's version, 895 KBLicence: CC BY

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@article{033add57f6134ab7b6e9df96ec39db85,

title = "Circular RNAs: Biogenesis, Mechanism, and Function in Human Cancers",

abstract = "CircRNAs are a class of noncoding RNA species with a circular configuration that is formed by either typical spliceosome-mediated or lariat-type splicing. The expression of circRNAs is usually abnormal in many cancers. Several circRNAs have been demonstrated to play important roles in carcinogenesis. In this review, we will first provide an introduction of circRNAs biogenesis, especially the regulation of circRNA by RNA-binding proteins, then we will focus on the recent findings of circRNA molecular mechanisms and functions in cancer development. Finally, some open questions are also discussed.",

keywords = "circRNAs, carcinogenesis, biogenesis, RNA-binding protein, flanking introns, genomic alternation, LANDSCAPE, CIRCHIPK3, PROTEINS, MICRORNA, ABUNDANT, REVEALS, MAP",

author = "Xing Zhao and Yujie Cai and Jianzhen Xu",

year = "2019",

month = aug,

day = "13",

doi = "10.3390/ijms20163926",

language = "English",

volume = "20",

journal = "International Journal of Molecular Sciences",

issn = "1661-6596",

publisher = "MDPI AG",

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TY - JOUR

T1 - Circular RNAs

T2 - Biogenesis, Mechanism, and Function in Human Cancers

AU - Zhao, Xing

AU - Cai, Yujie

AU - Xu, Jianzhen

PY - 2019/8/13

Y1 - 2019/8/13

N2 - CircRNAs are a class of noncoding RNA species with a circular configuration that is formed by either typical spliceosome-mediated or lariat-type splicing. The expression of circRNAs is usually abnormal in many cancers. Several circRNAs have been demonstrated to play important roles in carcinogenesis. In this review, we will first provide an introduction of circRNAs biogenesis, especially the regulation of circRNA by RNA-binding proteins, then we will focus on the recent findings of circRNA molecular mechanisms and functions in cancer development. Finally, some open questions are also discussed.

AB - CircRNAs are a class of noncoding RNA species with a circular configuration that is formed by either typical spliceosome-mediated or lariat-type splicing. The expression of circRNAs is usually abnormal in many cancers. Several circRNAs have been demonstrated to play important roles in carcinogenesis. In this review, we will first provide an introduction of circRNAs biogenesis, especially the regulation of circRNA by RNA-binding proteins, then we will focus on the recent findings of circRNA molecular mechanisms and functions in cancer development. Finally, some open questions are also discussed.

KW - circRNAs

KW - carcinogenesis

KW - biogenesis

KW - RNA-binding protein

KW - flanking introns

KW - genomic alternation

KW - LANDSCAPE

KW - CIRCHIPK3

KW - PROTEINS

KW - MICRORNA

KW - ABUNDANT

KW - REVEALS

KW - MAP

U2 - 10.3390/ijms20163926

DO - 10.3390/ijms20163926

M3 - Review article

SN - 1661-6596

VL - 20

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 16

M1 - 3926

ER -

Circular RNAs: Biogenesis, Mechanism, and Function in Human Cancers

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