Circulating biomarkers in classical Hodgkin lymphoma

Research output: ThesisThesis fully internal (DIV)

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Abstract

In classical Hodgkin lymphoma (cHL) there is an urgent need for biomarkers to determine prognosis or treatment response. In this thesis we summarized current knowledge on circulating biomarkers in cHL and studied a selection of these markers as treatment response or prognostic biomarkers. In the first part of this thesis we studied the application of Thymus and Activation Regulated Chemokine (TARC) as a biomarker for treatment response and compared TARC with sGal-1, sCD163 and sCD30 and interim FDG-PET imaging. We found that TARC at diagnosis correlates with metabolic tumor volume and that serial TARC measurements during and after treatment accurately reflect treatment response. In comparison to sGal-1, sCD163 and sCD30, TARC dynamics most accurately reflected treatment response. In addition, interim TARC had a higher positive predictive value for final treatment response compared to interim FDG-PET imaging. All together, we concluded that TARC is a cheap, non-invasive and highly accurate biomarker to determine treatment response in cHL patients.
In the second part of this thesis, we focused on microRNAs (miRNAs) as circulating biomarkers. We summarized the role of miRNAs in cHL and concluded that deregulation of miRNAs is a frequent event and an important factor in the pathobiology of cHL. Next, we summarized pre-analytical, analytical and post-analytical challenges in circulating miRNAs studies in general. Finally, we performed miRNA microarray profiling of serum of patients with cHL. Using this approach, we were unable to find circulating miRNAs with prognostic value in classical Hodgkin lymphoma.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • University of Groningen
Supervisors/Advisors
  • van den Berg, Anke, Supervisor
  • Kluin-Nelemans, Hanneke, Supervisor
  • van Imhoff, Gustaaf, Co-supervisor
  • Visser, Lydia, Co-supervisor
Award date16-Oct-2019
Place of Publication[Groningen]
Publisher
Print ISBNs978-94-034-1960-2
Electronic ISBNs978-94-034-1959-6
DOIs
Publication statusPublished - 2019

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