TY - JOUR
T1 - Circulating de novo lipogenesis fatty acids and all-cause mortality in a prospective Dutch population cohort
AU - Zhu, Yinjie
AU - Vogelpohl, Fabian A.
AU - Heiner-Fokkema, M. Rebecca
AU - Pranger, Ilse G.
AU - Minović, Isidor
AU - Navis, Gerjan J.
AU - Bakker, Stephan J.L.
AU - Riphagen, Ineke J.
N1 - Funding Information:
The authors wish to acknowledge the services of the Lifelines cohort study, the contributing research centers delivering data to Lifelines, and all the study participants. Data described in the manuscript, codebook, and analytic code will not be made available because the authors do not have the authority to share them according to Lifelines data access permissions. But any researchers can apply to use Lifelines data, including the variables used in this investigation. Information about access to Lifelines data is given on their website: (https://www.lifelines.nl/researcher/how-to-apply). None. Y.Z. S.J.L.B. G.J.N. and I.J.R. designed research; I.G.P. conducted research; F.A.V. M.R.H.F. and I.M. provided essential reagents and materials; Y.Z. and I.J.R. analyzed data and performed statistical analysis; Y.Z. G.J.N. and S.J.L.B. wrote the paper; I.G.P. F.A.V. M.R.H.F. and I.M. critically reviewed the manuscript; Y.Z. had primary responsibility for final content.
Publisher Copyright:
© 2022
PY - 2022/9
Y1 - 2022/9
N2 - Background: Circulating fatty acids (FA) from de novo lipogenesis (DNL) are associated with all-cause mortality in individuals with elevated CVD risk. However, compared to FA early in the DNL synthetic pathway, cis-vaccenic acid, one of the FA distal in the DNL synthetic pathway, has rarely been studied in a general population cohort. We hypothesized that circulating cis-vaccenic acid is more strongly related to all-cause mortality than other circulating DNL-related FA.Objectives: The primary and secondary objectives of this study were to investigate the prospective associations of plasma levels of cis-vaccenic acid and other DNL-related FA with all-cause mortality in a general population, respectively.Methods: We included 850 participants (mean ± SD age 53 ± 15 years) from the Dutch Lifelines cohort study. Circulating levels of palmitic (C16:0), palmitoleic (C16:1n7), cis-vaccenic (cis-C18:1n7), stearic (C18:0), oleic acid (C18:1n9) in plasma phospholipids (PL) and triglycerides (TG) were measured by gas chromatography. The associations of circulating cis-C18:1n7 and other DNL-related FA with all-cause mortality were assessed using Cox regression analyses.Results: During a median follow-up of 9.3 (IQR: 5.4–10.8) years, 34 (4.0%) participants had died. In plasma PL, a 1-SD increase in cis-C18:1n7 was associated with an increased risk of all-cause mortality in univariate and multivariate models (p<0.02 for all), with a HR [95% CI] of 1.60 [1.13–2.25] after adjustment for age and sex.Conclusions: Circulating plasma PL cis-C18:1n7 was associated with a higher risk for all-cause mortality. More studies are needed in different cohorts to verify and validate our results.
AB - Background: Circulating fatty acids (FA) from de novo lipogenesis (DNL) are associated with all-cause mortality in individuals with elevated CVD risk. However, compared to FA early in the DNL synthetic pathway, cis-vaccenic acid, one of the FA distal in the DNL synthetic pathway, has rarely been studied in a general population cohort. We hypothesized that circulating cis-vaccenic acid is more strongly related to all-cause mortality than other circulating DNL-related FA.Objectives: The primary and secondary objectives of this study were to investigate the prospective associations of plasma levels of cis-vaccenic acid and other DNL-related FA with all-cause mortality in a general population, respectively.Methods: We included 850 participants (mean ± SD age 53 ± 15 years) from the Dutch Lifelines cohort study. Circulating levels of palmitic (C16:0), palmitoleic (C16:1n7), cis-vaccenic (cis-C18:1n7), stearic (C18:0), oleic acid (C18:1n9) in plasma phospholipids (PL) and triglycerides (TG) were measured by gas chromatography. The associations of circulating cis-C18:1n7 and other DNL-related FA with all-cause mortality were assessed using Cox regression analyses.Results: During a median follow-up of 9.3 (IQR: 5.4–10.8) years, 34 (4.0%) participants had died. In plasma PL, a 1-SD increase in cis-C18:1n7 was associated with an increased risk of all-cause mortality in univariate and multivariate models (p<0.02 for all), with a HR [95% CI] of 1.60 [1.13–2.25] after adjustment for age and sex.Conclusions: Circulating plasma PL cis-C18:1n7 was associated with a higher risk for all-cause mortality. More studies are needed in different cohorts to verify and validate our results.
KW - Epidemiology
KW - Fatty acids
KW - Lipid metabolism
KW - Lipogenesis
KW - Population studies
U2 - 10.1016/j.jacl.2022.07.003
DO - 10.1016/j.jacl.2022.07.003
M3 - Article
AN - SCOPUS:85135141370
SN - 1933-2874
VL - 16
SP - 658
EP - 666
JO - Journal of Clinical Lipidology
JF - Journal of Clinical Lipidology
IS - 5
ER -