Circulating fatty acids as biomarkers of dairy fat intake: Data from the Lifelines Biobank and Cohort Study

Ilse G Pranger; Eva Corpeleijn; Frits A J Muskiet; Ido P Kema; Cécile Singh-Povel; Stephan J L Bakker

doi:10.1080/1354750X.2019.1583770

Circulating fatty acids as biomarkers of dairy fat intake: Data from the Lifelines Biobank and Cohort Study

Ilse G Pranger, Eva Corpeleijn, Frits A J Muskiet, Ido P Kema, Cécile Singh-Povel, Stephan J L Bakker

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

BACKGROUND: C14:0, C15:0, C17:0 and trans-C16:1(n-7) are often used as biomarkers for dairy fat intake. Trans-C18:1(n-7) and CLA, two fatty acids which are also present in dairy, have hardly been explored. We investigated whether trans-C18:1(n-7) and CLA can enrich the existing biomarker portfolio.

METHODS: Data were obtained from Lifelines (n = 769). Dairy fat intake was determined by FFQ. Fatty acids were measured in fasting plasma triglycerides (TG), phospholipids (PL) and cholesterol esters (CE).

RESULTS: Median(25th-75th percentile) intakes of dairy and dairy fat were 322(209-447) and 12.3(8.4-17.4) g/d respectively. A pilot study showed that trans-C18:1(n-7) and CLA were only detectable in TG and PL. Of the established markers, TG C15:0 was most strongly associated with dairy fat intake (standardized β (std.β)=0.286, R2 = 0.111). Of the less established markers, TG trans-C18:1(n-7) was most strongly associated with dairy fat intake (Std.β = 0.292, R2 = 0.115), followed by PL CLA (Std.β = 0.272, R2 = 0.103) and PL trans-C18:1(n-7) (Std.β = 0.269, R2 = 0.099). In TG, a combination of C15:0 and trans-C18:1(n-7) performed best (R2 = 0.128). In PL, a combination of C14:0, C15:0, trans-C18:1(n-7) and CLA performed best (R2 = 0.143).

CONCLUSION: Trans-C18:1(n-7) and CLA can be used as biomarkers of dairy fat intake. Additionally, combining established with less established markers allowed even stronger predictions for dairy fat intake.

Original language	English
Pages (from-to)	360-372
Number of pages	13
Journal	Biomarkers
Volume	24
Issue number	4
DOIs	https://doi.org/10.1080/1354750X.2019.1583770
Publication status	Published - 28-May-2019

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10.1080/1354750X.2019.1583770

Circulating fatty acids as biomarkers of dairy fat intakeFinal publisher's version, 1.72 MBLicence: Taverne

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Lifelines Biobank
Bakker, S. (Creator), Dotinga, A. (Creator), Vonk, J. M. (Creator), Smidt, N. (Creator), Scholtens, S. (Creator), Swertz, M. (Creator), Wijmenga, C. (Creator), Wolffenbutel, B. H. (Creator), Stolk, R. (Creator), van Zon, S. (Creator), Rosmalen, J. (Creator), Postma, D. S. (Creator), de Boer, R. (Creator), Navis, G. (Creator), Slaets, J. (Creator), Ormel, J. (Creator), van Dijk, F. (Creator) & Bolmer, B. (Data Manager), Lifelines, 2006
https://www.lifelines.nl/ and one more link, https://catalogue.lifelines.nl/ (show fewer)
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@article{80f04855437947deaad70db5f14a0ae0,

title = "Circulating fatty acids as biomarkers of dairy fat intake: Data from the Lifelines Biobank and Cohort Study",

abstract = "BACKGROUND: C14:0, C15:0, C17:0 and trans-C16:1(n-7) are often used as biomarkers for dairy fat intake. Trans-C18:1(n-7) and CLA, two fatty acids which are also present in dairy, have hardly been explored. We investigated whether trans-C18:1(n-7) and CLA can enrich the existing biomarker portfolio.METHODS: Data were obtained from Lifelines (n = 769). Dairy fat intake was determined by FFQ. Fatty acids were measured in fasting plasma triglycerides (TG), phospholipids (PL) and cholesterol esters (CE).RESULTS: Median(25th-75th percentile) intakes of dairy and dairy fat were 322(209-447) and 12.3(8.4-17.4) g/d respectively. A pilot study showed that trans-C18:1(n-7) and CLA were only detectable in TG and PL. Of the established markers, TG C15:0 was most strongly associated with dairy fat intake (standardized β (std.β)=0.286, R2 = 0.111). Of the less established markers, TG trans-C18:1(n-7) was most strongly associated with dairy fat intake (Std.β = 0.292, R2 = 0.115), followed by PL CLA (Std.β = 0.272, R2 = 0.103) and PL trans-C18:1(n-7) (Std.β = 0.269, R2 = 0.099). In TG, a combination of C15:0 and trans-C18:1(n-7) performed best (R2 = 0.128). In PL, a combination of C14:0, C15:0, trans-C18:1(n-7) and CLA performed best (R2 = 0.143).CONCLUSION: Trans-C18:1(n-7) and CLA can be used as biomarkers of dairy fat intake. Additionally, combining established with less established markers allowed even stronger predictions for dairy fat intake.",

author = "Pranger, {Ilse G} and Eva Corpeleijn and Muskiet, {Frits A J} and Kema, {Ido P} and C{\'e}cile Singh-Povel and Bakker, {Stephan J L}",

year = "2019",

month = may,

day = "28",

doi = "10.1080/1354750X.2019.1583770",

language = "English",

volume = "24",

pages = "360--372",

journal = "Biomarkers",

issn = "1354-750X",

publisher = "Taylor & Francis Group",

number = "4",

}

TY - JOUR

T1 - Circulating fatty acids as biomarkers of dairy fat intake

T2 - Data from the Lifelines Biobank and Cohort Study

AU - Pranger, Ilse G

AU - Corpeleijn, Eva

AU - Muskiet, Frits A J

AU - Kema, Ido P

AU - Singh-Povel, Cécile

AU - Bakker, Stephan J L

PY - 2019/5/28

Y1 - 2019/5/28

N2 - BACKGROUND: C14:0, C15:0, C17:0 and trans-C16:1(n-7) are often used as biomarkers for dairy fat intake. Trans-C18:1(n-7) and CLA, two fatty acids which are also present in dairy, have hardly been explored. We investigated whether trans-C18:1(n-7) and CLA can enrich the existing biomarker portfolio.METHODS: Data were obtained from Lifelines (n = 769). Dairy fat intake was determined by FFQ. Fatty acids were measured in fasting plasma triglycerides (TG), phospholipids (PL) and cholesterol esters (CE).RESULTS: Median(25th-75th percentile) intakes of dairy and dairy fat were 322(209-447) and 12.3(8.4-17.4) g/d respectively. A pilot study showed that trans-C18:1(n-7) and CLA were only detectable in TG and PL. Of the established markers, TG C15:0 was most strongly associated with dairy fat intake (standardized β (std.β)=0.286, R2 = 0.111). Of the less established markers, TG trans-C18:1(n-7) was most strongly associated with dairy fat intake (Std.β = 0.292, R2 = 0.115), followed by PL CLA (Std.β = 0.272, R2 = 0.103) and PL trans-C18:1(n-7) (Std.β = 0.269, R2 = 0.099). In TG, a combination of C15:0 and trans-C18:1(n-7) performed best (R2 = 0.128). In PL, a combination of C14:0, C15:0, trans-C18:1(n-7) and CLA performed best (R2 = 0.143).CONCLUSION: Trans-C18:1(n-7) and CLA can be used as biomarkers of dairy fat intake. Additionally, combining established with less established markers allowed even stronger predictions for dairy fat intake.

AB - BACKGROUND: C14:0, C15:0, C17:0 and trans-C16:1(n-7) are often used as biomarkers for dairy fat intake. Trans-C18:1(n-7) and CLA, two fatty acids which are also present in dairy, have hardly been explored. We investigated whether trans-C18:1(n-7) and CLA can enrich the existing biomarker portfolio.METHODS: Data were obtained from Lifelines (n = 769). Dairy fat intake was determined by FFQ. Fatty acids were measured in fasting plasma triglycerides (TG), phospholipids (PL) and cholesterol esters (CE).RESULTS: Median(25th-75th percentile) intakes of dairy and dairy fat were 322(209-447) and 12.3(8.4-17.4) g/d respectively. A pilot study showed that trans-C18:1(n-7) and CLA were only detectable in TG and PL. Of the established markers, TG C15:0 was most strongly associated with dairy fat intake (standardized β (std.β)=0.286, R2 = 0.111). Of the less established markers, TG trans-C18:1(n-7) was most strongly associated with dairy fat intake (Std.β = 0.292, R2 = 0.115), followed by PL CLA (Std.β = 0.272, R2 = 0.103) and PL trans-C18:1(n-7) (Std.β = 0.269, R2 = 0.099). In TG, a combination of C15:0 and trans-C18:1(n-7) performed best (R2 = 0.128). In PL, a combination of C14:0, C15:0, trans-C18:1(n-7) and CLA performed best (R2 = 0.143).CONCLUSION: Trans-C18:1(n-7) and CLA can be used as biomarkers of dairy fat intake. Additionally, combining established with less established markers allowed even stronger predictions for dairy fat intake.

U2 - 10.1080/1354750X.2019.1583770

DO - 10.1080/1354750X.2019.1583770

M3 - Article

C2 - 30773031

SN - 1354-750X

VL - 24

SP - 360

EP - 372

JO - Biomarkers

JF - Biomarkers

IS - 4

ER -

Circulating fatty acids as biomarkers of dairy fat intake: Data from the Lifelines Biobank and Cohort Study

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