Circulating microparticles in cardiovascular disease: Implications for atherogenesis and atherothrombosis

E. Shantsila, P.W. Kamphuisen, G.Y.H. Lip

Research output: Contribution to journalBook/Film/Article reviewProfessional

127 Citations (Scopus)

Abstract

The complex and multifactorial nature of atherogenesis and development of atherothrombotic complications involves numerous interactions between various cell types inside the vascular wall (e.g. macrophages and smooth muscle cells) and in the blood (e.g. leukocytes and platelets). One relatively recent advance in this area is the discovery of circulating microparticles and their role in endothelial damage, platelet activation, hypercoagulability and regulation of inter-cellular interactions. Microparticles are small anucleoid phospholipid vesicles released from different cells, such as platelets, erythrocytes, leukocytes and endothelial cells. Microparticles carry surface proteins and include cytoplasmic material of the parental cells responsible for the exertion of microparticle-mediated biological effects. About 25% of the procoagulant activity of stimulated platelet suspensions is associated with microparticles released upon platelet activation and their surface may be approximately 50-100-fold more procoagulant than the surface of activated platelets per se. The available lines of evidence indicate that shedding of microparticles from the parental cells is not just a passive process accompanying cellular dysfunction and apoptosis, but a tightly regulated mechanism implicated in the interactions between various cell types. The role of microparticles as biological messengers is supported by their differential and specific involvement in the pathophysiology of different cardiovascular disorders, including atherogogenesis and thrombosis. © 2010 International Society on Thrombosis and Haemostasis.
Original languageEnglish
Pages (from-to)2358-2368
Number of pages11
JournalJOURNAL OF THROMBOSIS AND HAEMOSTASIS
Volume8
Issue number11
DOIs
Publication statusPublished - 1-Nov-2010
Externally publishedYes

Keywords

  • Atherosclerosis
  • Atherothrombosis
  • Endothelium
  • Microparticles
  • Platelets
  • anticoagulant agent
  • biological marker
  • CD146 antigen
  • CD31 antigen
  • beta3 integrin
  • endoglin
  • fibrinogen receptor
  • fibrinogen receptor antagonist
  • glycoprotein Ib alpha
  • icosapentaenoic acid
  • pitavastatin
  • procoagulant
  • tenecteplase
  • thrombin antithrombin complex
  • vascular endothelial cadherin
  • acute coronary syndrome
  • acute heart infarction
  • acute pulmonary embolism
  • angiogenesis
  • artery disease
  • atherogenesis
  • thrombosis
  • blood clot lysis
  • blood vessel injury
  • brain infarction
  • cardiovascular disease
  • cardiovascular risk
  • carotid atherosclerosis
  • cell suspension
  • cells by body anatomy
  • coronary artery disease
  • coronary artery obstruction
  • coronary stent
  • diabetes mellitus
  • endothelial microparticle
  • endothelium cell
  • fibrin formation
  • heart infarction
  • human
  • hypercholesterolemia
  • hyperlipidemia
  • hypertension
  • leukocyte microparticle
  • lung embolism
  • membrane microparticle
  • multiinfarct dementia
  • nonhuman
  • obesity
  • occlusive cerebrovascular disease
  • pathophysiology
  • platelet microparticle
  • priority journal
  • review
  • smoking
  • ST segment elevation myocardial infarction
  • cerebrovascular accident
  • thrombocyte activation
  • thrombocyte membrane
  • thromboembolism
  • blood clotting
  • transient ischemic attack
  • unstable angina pectoris
  • vein thrombosis

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