Circulating microRNAs in patients with acute heart failure

Adriaan Alexander Voors (Inventor), Ekaterina Sergeevna Ovchinnikova (Inventor), Eugene Berezikov (Inventor), Peter van der Meer (Inventor)

Research output: Patent

Abstract

The invention relates to diagnosis, prognosis or classification of acute heart failure (AHF) using circulating micro RNAs as molecular markers. Provided is a method of determining whether a subject has AHF, is at increased risk of developing AHF, or has AHF that is progressing, comprising measuring in a test sample obtained from the subject at least four mi RNAs selected from the group consisting of mi R-18a-5p, mi R-26b-5p, mi R-27a-3p, mi R-30e-5p, mi R-106a-5p, mi R-199a-3p, and mi R-652-3p. Also provided is a diagnostic kit comprising a plurality of primers and/or probes specific for determining expression levels at least four of mi R-18a-5p, mi R- 26b-5p, mi R-27a-3p, mi R-30e-5p, mi R-106a-5p, mi R-199a-3p, and mi R-652- 3p.
Original languageEnglish
Patent numberWO2016133395
Priority date20/02/2015
Publication statusPublished - 25-Aug-2016

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