Circulating monocytes in patients with acute coronary syndromes lack sufficient interleukin-10 production after lipopolysaccharide stimulation

PL van Haelst; JWC Tervaert; J Bijzet; C Balje-Volkers; JF May; B Langeveld; ROB Gans

doi:10.1111/j.1365-2249.2004.02602.x

Circulating monocytes in patients with acute coronary syndromes lack sufficient interleukin-10 production after lipopolysaccharide stimulation

PL van Haelst^*
, JWC Tervaert
, J Bijzet
, C Balje-Volkers
, JF May
, B Langeveld
, ROB Gans

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

14 Citations (Scopus)

Abstract

Acute coronary syndromes (ACS) are associated with inflammation resulting from monocyte activation. We sought for differences in the production of pro- and anti-inflammatory cytokines by monocytes from patients with ACS. C-reactive protein (CRP) and neopterin were measured in 22 patients with acute coronary syndromes, 50 patients with stable vascular disease and 22 healthy controls. Production of tumour necrosis factor (TNF)-alpha and interleukin (IL)-10 was determined after, respectively, 6 and 24 h of incubation of full blood with lipopolysaccharide (LPS). Levels of CRP [median, interquartile range (IQR)][1.5 mg/l (0.8-4.5) ACS patient versus 2.1 (0.9-3.6) stable disease versus 0.4 (0.3-1.2) healthy controls] (P

Original language	English
Pages (from-to)	364-368
Number of pages	5
Journal	Clinical and Experimental Immunology
Volume	138
Issue number	2
DOIs	https://doi.org/10.1111/j.1365-2249.2004.02602.x
Publication status	Published - Nov-2004

Keywords

acute coronary syndromes
atherosclerosis
IL-10
inflammation
monocyte activation
C-REACTIVE PROTEIN
UNSTABLE ANGINA
SERUM NEOPTERIN
ATHEROSCLEROSIS
DISEASE
IMMUNITY
IL-10
CELLS
RISK
MEN

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title = "Circulating monocytes in patients with acute coronary syndromes lack sufficient interleukin-10 production after lipopolysaccharide stimulation",

abstract = "Acute coronary syndromes (ACS) are associated with inflammation resulting from monocyte activation. We sought for differences in the production of pro- and anti-inflammatory cytokines by monocytes from patients with ACS. C-reactive protein (CRP) and neopterin were measured in 22 patients with acute coronary syndromes, 50 patients with stable vascular disease and 22 healthy controls. Production of tumour necrosis factor (TNF)-alpha and interleukin (IL)-10 was determined after, respectively, 6 and 24 h of incubation of full blood with lipopolysaccharide (LPS). Levels of CRP [median, interquartile range (IQR)][1.5 mg/l (0.8-4.5) ACS patient versus 2.1 (0.9-3.6) stable disease versus 0.4 (0.3-1.2) healthy controls] (P",

keywords = "acute coronary syndromes, atherosclerosis, IL-10, inflammation, monocyte activation, C-REACTIVE PROTEIN, UNSTABLE ANGINA, SERUM NEOPTERIN, ATHEROSCLEROSIS, DISEASE, IMMUNITY, IL-10, CELLS, RISK, MEN",

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year = "2004",

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doi = "10.1111/j.1365-2249.2004.02602.x",

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T1 - Circulating monocytes in patients with acute coronary syndromes lack sufficient interleukin-10 production after lipopolysaccharide stimulation

AU - van Haelst, PL

AU - Tervaert, JWC

AU - Bijzet, J

AU - Balje-Volkers, C

AU - May, JF

AU - Langeveld, B

AU - Gans, ROB

PY - 2004/11

Y1 - 2004/11

N2 - Acute coronary syndromes (ACS) are associated with inflammation resulting from monocyte activation. We sought for differences in the production of pro- and anti-inflammatory cytokines by monocytes from patients with ACS. C-reactive protein (CRP) and neopterin were measured in 22 patients with acute coronary syndromes, 50 patients with stable vascular disease and 22 healthy controls. Production of tumour necrosis factor (TNF)-alpha and interleukin (IL)-10 was determined after, respectively, 6 and 24 h of incubation of full blood with lipopolysaccharide (LPS). Levels of CRP [median, interquartile range (IQR)][1.5 mg/l (0.8-4.5) ACS patient versus 2.1 (0.9-3.6) stable disease versus 0.4 (0.3-1.2) healthy controls] (P

AB - Acute coronary syndromes (ACS) are associated with inflammation resulting from monocyte activation. We sought for differences in the production of pro- and anti-inflammatory cytokines by monocytes from patients with ACS. C-reactive protein (CRP) and neopterin were measured in 22 patients with acute coronary syndromes, 50 patients with stable vascular disease and 22 healthy controls. Production of tumour necrosis factor (TNF)-alpha and interleukin (IL)-10 was determined after, respectively, 6 and 24 h of incubation of full blood with lipopolysaccharide (LPS). Levels of CRP [median, interquartile range (IQR)][1.5 mg/l (0.8-4.5) ACS patient versus 2.1 (0.9-3.6) stable disease versus 0.4 (0.3-1.2) healthy controls] (P

KW - acute coronary syndromes

KW - atherosclerosis

KW - IL-10

KW - inflammation

KW - monocyte activation

KW - C-REACTIVE PROTEIN

KW - UNSTABLE ANGINA

KW - SERUM NEOPTERIN

KW - ATHEROSCLEROSIS

KW - DISEASE

KW - IMMUNITY

KW - IL-10

KW - CELLS

KW - RISK

KW - MEN

U2 - 10.1111/j.1365-2249.2004.02602.x

DO - 10.1111/j.1365-2249.2004.02602.x

M3 - Article

SN - 0009-9104

VL - 138

SP - 364

EP - 368

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

IS - 2

ER -

Circulating monocytes in patients with acute coronary syndromes lack sufficient interleukin-10 production after lipopolysaccharide stimulation

Abstract

Keywords

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