Clinical and spinal radiographic outcome in axial spondyloarthritis: Results from the GLAS cohort

Fiona Maas

    Research output: ThesisThesis fully internal (DIV)

    1384 Downloads (Pure)

    Abstract

    The Groningen Leeuwarden Axial Spondyloarthritis (GLAS) cohort is an ongoing, prospective, longitudinal, observational cohort study collecting data from axial SpA patients. This cohort is embedded in daily clinical practice of the University Medical Center Groningen (UMCG) and the Medical Center Leeuwarden (MCL), The Netherlands. Axial SpA patients in this cohort are treated and monitored according to the latest (inter)national guidelines. The overall objective of the GLAS cohort is to combine up-to-date clinical care with clinical and translational research to gain more knowledge about the long-term course of axial SpA.

    In this thesis, clinical and radiographic data from the GLAS cohort were analyzed. The key findings were: 1) small reduction in spinal radiographic progression during long-term treatment with TNF-α inhibitors, 2) frequent involvement of cervical facet joints, 3) relatively high prevalence and incidence of radiographic vertebral fractures, 4) identification of risk factors (e.g. smoking and obesity) for high disease activity and poor disease outcome, 5) gender differences in patient-reported outcome measures, and 6) a new, disease-specific questionnaire to assess daily physical activity in axial SpA.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    Supervisors/Advisors
    • Bootsma, Hendrika, Supervisor
    • Spoorenberg, Anneke, Co-supervisor
    • Boezerooij-Arends, Suzanne, Co-supervisor
    • van der Heijde, Desiree M. F. M., Assessment committee, External person
    • Lems, W.F., Assessment committee, External person
    • Boers, M, Assessment committee, External person
    Award date8-Mar-2017
    Place of Publication[Groningen]
    Publisher
    Print ISBNs978-90-367-9645-3
    Electronic ISBNs978-90-367-9644-6
    Publication statusPublished - 2017

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