Clinical applications of laser speckle contrast imaging: a review

Wido Heeman, Wiendelt Steenbergen, Gooitzen van Dam, E Christiaan Boerma

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Abstract

When a biological tissue is illuminated with coherent light, an interference pattern will be formed at the detector, the so-called speckle pattern. Laser speckle contrast imaging (LSCI) is a technique based on the dynamic change in this backscattered light as a result of interaction with red blood cells. It can be used to visualize perfusion in various tissues and, even though this technique has been extensively described in the literature, the actual clinical implementation lags behind. We provide an overview of LSCI as a tool to image tissue perfusion. We present a brief introduction to the theory, review clinical studies from various medical fields, and discuss current limitations impeding clinical acceptance.
Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalJournal of Biomedical Optics
Volume24
Issue number8
DOIs
Publication statusPublished - Aug-2019

Keywords

  • MICROVASCULAR ENDOTHELIAL FUNCTION
  • TISSUE BLOOD-FLOW
  • OPTIC-NERVE HEAD
  • TARGETED PHOTODYNAMIC THERAPY
  • PULSE-WAVE ANALYSIS
  • PORT-WINE STAINS
  • TERM FOLLOW-UP
  • SYSTEMIC-SCLEROSIS
  • INTRAOPERATIVE ASSESSMENT
  • OCULAR CIRCULATION

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